Gene
hif1aa
- ID
- ZDB-GENE-080917-55
- Name
- hypoxia inducible factor 1 subunit alpha a
- Symbol
- hif1aa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including Notch signaling pathway; hematopoietic stem cell differentiation; and macrophage migration. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; eye; gill; heart; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in carcinoma (multiple); diabetic retinopathy; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Gerri et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000014 | PAS domain |
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR013767 | PAS fold |
| Domain | IPR014887 | HIF-1 alpha, C-terminal transactivation domain |
| Domain | IPR021537 | Hypoxia-inducible factor, alpha subunit-like |
| Homologous_superfamily | IPR035965 | PAS domain superfamily |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
| Repeat | IPR001610 | PAC motif |
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | HIF-1 alpha, C-terminal transactivation domain | Hypoxia-inducible factor, alpha subunit-like | Myc-type, basic helix-loop-helix (bHLH) domain | PAC motif | PAS domain | PAS domain superfamily | PAS fold |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QNB9 | InterPro | 717 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
hif1aa-202
(1)
|
Ensembl | 1,294 nt | ||
| mRNA |
hif1aa-201
(1)
|
Ensembl | 2,154 nt | ||
| mRNA |
hif1aa-203
(1)
|
Ensembl | 2,204 nt |
Interactions and Pathways
No data available
Plasmids
No data available