Gene
asgr1a
- ID
- ZDB-GENE-080917-52
- Name
- asialoglycoprotein receptor 1a
- Symbol
- asgr1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable carbohydrate binding activity and pattern recognition receptor activity. Predicted to be involved in immune response. Located in plasma membrane. Is expressed in several structures, including gill; head; heart; liver; and pleuroperitoneal region. Orthologous to human CLEC10A (C-type lectin domain containing 10A); ASGR1 (asialoglycoprotein receptor 1); and ASGR2 (asialoglycoprotein receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7166074 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001304 | C-type lectin-like |
Domain | IPR033989 | CD209-like, C-type lectin-like domain |
Family | IPR050111 | C-type lectin and snaclec domain-containing protein |
Homologous_superfamily | IPR016186 | C-type lectin-like/link domain superfamily |
Homologous_superfamily | IPR016187 | C-type lectin fold |
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Domain Details Per Protein
Protein | Additional Resources | Length | CD209-like, C-type lectin-like domain | C-type lectin and snaclec domain-containing protein | C-type lectin fold | C-type lectin-like | C-type lectin-like/link domain superfamily |
---|---|---|---|---|---|---|---|
UniProtKB:F8W3Q0 | InterPro | 299 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
asgrl2-202
(1)
|
Ensembl | 900 nt | ||
mRNA |
si:ch73-361h17.1-201
(1)
|
Ensembl | 2,012 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-361H17 | ZFIN Curated Data | |
Encodes | EST | IMAGE:7166074 | Thisse et al., 2004 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_005170599 (1) | 1879 nt | ||
Genomic | RefSeq:NW_018395163 (1) | 125453 nt | ||
Polypeptide | UniProtKB:F8W3Q0 (1) | 299 aa |
Species | Symbol | Chromosome | Accession # | Evidence |
---|---|---|---|---|
Human | ASGR1 | 17 | Phylogenetic tree (1) Amino acid sequence comparison (1) | |
Human | ASGR2 | 17 | Phylogenetic tree (1) Amino acid sequence comparison (1) | |
Mouse | Asgr1 | 11 | Amino acid sequence comparison (1) Phylogenetic tree (1) | |
Mouse | Asgr2 | 11 | Phylogenetic tree (1) Amino acid sequence comparison (1) |
- Yang, Q., Wang, P., Yang, S., Li, X., Zhang, X., Ji, G., Zhang, S., Wang, S., Li, H. (2019) A novel hepatic lectin of zebrafish Danio rerio is involved in innate immune defense. Fish & shellfish immunology. 98:670-680
- Yang, Q., Wang, P., Wang, S., Wang, Y., Feng, S., Zhang, S., Li, H. (2018) The hepatic lectin of zebrafish binds a wide range of bacteria and participates in immune defense. Fish & shellfish immunology. 82:267-278
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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