Gene
ca12
- ID
- ZDB-GENE-080815-4
- Name
- carbonic anhydrase XII
- Symbol
- ca12 Nomenclature History
- Previous Names
-
- si:dkeyp-73b11.11
- zmp:0000000627
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable carbonate dehydratase activity and zinc ion binding activity. Predicted to be located in membrane. Is expressed in muscle. Human ortholog(s) of this gene implicated in isolated hyperchlorhidrosis and lung non-small cell carcinoma. Orthologous to human CA12 (carbonic anhydrase 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Esbaugh et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| isolated hyperchlorhidrosis | Alliance | Hyperchlorhidrosis, isolated | 143860 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018338 | Carbonic anhydrase, alpha-class, conserved site |
| Domain | IPR001148 | Alpha carbonic anhydrase domain |
| Family | IPR018430 | Carbonic anhydrase, CA-XII |
| Family | IPR023561 | Carbonic anhydrase, alpha-class |
| Homologous_superfamily | IPR036398 | Alpha carbonic anhydrase domain superfamily |
Domain Details Per Protein
| Protein | Length | Alpha carbonic anhydrase domain | Alpha carbonic anhydrase domain superfamily | Carbonic anhydrase, alpha-class | Carbonic anhydrase, alpha-class, conserved site | Carbonic anhydrase, CA-XII |
|---|---|---|---|---|---|---|
|
UniProtKB:X1WD95
|
257 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance