Gene
ca12
- ID
- ZDB-GENE-080815-4
- Name
- carbonic anhydrase XII
- Symbol
- ca12 Nomenclature History
- Previous Names
-
- si:dkeyp-73b11.11
- zmp:0000000627
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Is expressed in muscle. Human ortholog(s) of this gene implicated in isolated hyperchlorhidrosis and lung non-small cell carcinoma. Orthologous to human CA12 (carbonic anhydrase 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Esbaugh et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa5708 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9058 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9295 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10344 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44316 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| isolated hyperchlorhidrosis | Alliance | Hyperchlorhidrosis, isolated | 143860 |
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Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-73B11 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| Genomic | GenBank:CR391977 | 189510 nt |
- Comparative Orthology
- Alliance
- Matsumoto, H., Fujiwara, S., Miyagi, H., Nakamura, N., Shiga, Y., Ohta, T., Tsuzuki, M. (2017) Carbonic Anhydrase Inhibitors Induce Developmental Toxicity During Zebrafish Embryogenesis, Especially in the Inner Ear. Marine biotechnology (New York, N.Y.). 19(5):430-440
- Patrikainen, M.S., Tolvanen, M.E.E., Aspatwar, A., Barker, H.R., Ortutay, C., Jänis, J., Laitaoja, M., Hytönen, V.P., Azizi, L., Manandhar, P., Jáger, E., Vullo, D., Kukkurainen, S., Hilvo, M., Supuran, C.T., Parkkila, S. (2017) Identification and characterization of a novel zebrafish (Danio rerio) pentraxin-carbonic anhydrase.. PeerJ. 5:e4128
- Esbaugh, A.J., Perry, S.F., and Gilmour, K.M. (2009) Hypoxia-inducible carbonic anhydrase IX expression is insufficient to alleviate intracellular metabolic acidosis in the muscle of zebrafish, Danio rerio. American journal of physiology. Regulatory, integrative and comparative physiology. 296(1):R150-R160
- Lin, T.Y., Liao, B.K., Horng, J.L., Yan, J.J., Hsiao, C.D., and Hwang, P.P. (2008) Carbonic anhydrase 2-like a and 15a are involved in acid-base regulation and Na+ uptake in zebrafish H+-ATPase-rich cells. American journal of physiology. Cell physiology. 294(5):C1250-C1260
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