Gene
pcdh18b
- ID
- ZDB-GENE-080804-1
- Name
- protocadherin 18b
- Symbol
- pcdh18b Nomenclature History
- Previous Names
-
- pcdh18 (1)
- fj19f12
- wu:fj19f12
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within neuron projection morphogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including head; nervous system; neural rod; pectoral fin bud; and spinal cord neural tube. Orthologous to human PCDH18 (protocadherin 18).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Biswas et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh513 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| os71 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa7396 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa10255 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22533 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cadherin conserved site | Cadherin-like | Cadherin-like superfamily | Cadherin, N-terminal | Protocadherin/Cadherin-related Cell Adhesion |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B3M4 | InterPro | 840 | |||||
| UniProtKB:A9CPE6 | InterPro | 1150 | |||||
| UniProtKB:A0A8M2B3F9 | InterPro | 1161 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pcdh18b-201
(1)
|
Ensembl | 4,372 nt | ||
| mRNA |
pcdh18b-202
(1)
|
Ensembl | 3,645 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-154P8 | ||
| Contained in | BAC | DKEY-86P22 | ||
| Encodes | EST | fj19f12 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001115099 (1) | 3689 nt | ||
| Genomic | GenBank:BX537109 (2) | 231134 nt | ||
| Polypeptide | UniProtKB:A0A8M2B3F9 (1) | 1161 aa |
- Tsai, T.Y., Sikora, M., Xia, P., Colak-Champollion, T., Knaut, H., Heisenberg, C.P., Megason, S.G. (2020) An adhesion code ensures robust pattern formation during tissue morphogenesis. Science (New York, N.Y.). 370:113-116
- Laboissonniere, L.A., Smith, C.L., Mesenbrink, J., Chowdhury, R., Burney, A., Lang, M., Sierra, M., Stark, A., Maldonado-Casalduc, G., Muller, M., Trimarchi, J.M. (2018) ALS-associated genes display CNS expression in the developing zebrafish. Gene expression patterns : GEP. 30:14-31
- Williams, J.S., Hsu, J.Y., Rossi, C.C., Artinger, K.B. (2018) Requirement of zebrafish pcdh10a and pcdh10b in melanocyte precursor migration. Developmental Biology. 444 Suppl 1:S274-S286
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Cooper, S.R., Emond, M.R., Duy, P.Q., Liebau, B.G., Wolman, M.A., Jontes, J.D. (2015) Protocadherins control the modular assembly of neuronal columns in the zebrafish optic tectum. The Journal of cell biology. 211:807-14
- Esain, V., Kwan, W., Carroll, K.J., Cortes, M., Liu, S.Y., Frechette, G.M., Sheward, L.M., Nissim, S., Goessling, W., North, T.E. (2015) Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via PGE2 and P-selectin Activity. Stem cells (Dayton, Ohio). 33(8):2596-612
- Biswas, S., Duy, P.Q., Hao le, T., Beattie, C.E., and Jontes, J.D. (2014) Protocadherin-18b interacts with Nap1 to control motor axon growth and arborization in zebrafish. Molecular biology of the cell. 25(5):633-42
- Okuda, Y., Ogura, E., Kondoh, H., and Kamachi, Y. (2010) B1 SOX coordinate cell specification with patterning and morphogenesis in the early zebrafish embryo. PLoS Genetics. 6:e1000936
- Aamar, E., and Dawid, I.B. (2008) Protocadherin-18a has a role in cell adhesion, behavior and migration in zebrafish development. Developmental Biology. 318(2):335-346
- Kubota, F., Murakami, T., Tajika, Y., and Yorifuji, H. (2008) Expression of protocadherin 18 in the CNS and pharyngeal arches of zebrafish embryos. The International journal of developmental biology. 52(4):397-405
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