Gene
pcgf5a
- ID
- ZDB-GENE-080723-33
- Name
- polycomb group ring finger 5a
- Symbol
- pcgf5a Nomenclature History
- Previous Names
-
- zgc:194668
- zgc:194700 (1)
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Acts upstream of or within nervous system development. Predicted to be located in nucleus. Predicted to be part of PRC1 complex. Is expressed in eye; gonad; and muscle. Orthologous to human PCGF5 (polycomb group ring finger 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Yang et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa23073 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Polycomb group RING finger | RAWUL domain | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site |
|---|---|---|---|---|---|---|---|
| UniProtKB:B3DK16 | InterPro | 234 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pcgf5a-201
(1)
|
Ensembl | 1,166 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-28J9 | ||
| Encodes | cDNA | MGC:194668 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194700 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128712 (1) | 1092 nt | ||
| Genomic | GenBank:BX649437 (1) | 158346 nt | ||
| Polypeptide | UniProtKB:B3DK16 (1) | 234 aa |
- Yang, X., Zhou, W., Zhou, J., Li, A., Zhang, C., Fang, Z., Wang, C., Liu, S., Hao, A., Zhang, M. (2024) Pcgf5: An important regulatory factor in early embryonic neural induction. Heliyon. 10:e27634e27634
- Boskovic, S., Marín-Juez, R., Jasnic, J., Reischauer, S., El Sammak, H., Kojic, A., Faulkner, G., Radojkovic, D., Stainier, D.Y.R., Kojic, S. (2018) Characterization of zebrafish (Danio rerio) muscle ankyrin repeat proteins reveals their conserved response to endurance exercise. PLoS One. 13:e0204312
- Chrispijn, N.D., Andralojc, K.M., Castenmiller, C., Kamminga, L.M. (2018) Gene expression profile of a selection of Polycomb Group genes during zebrafish embryonic and germ line development. PLoS One. 13:e0200316
- Li, Y., Sun, S., Ding, Z., Yang, C., Zhang, G., Jiang, Q., Zou, Y. (2018) Temporal and spatial expression of fgfbp genes in zebrafish. Gene. 659:128-136
- Dupret, B., Völkel, P., Le Bourhis, X., Angrand, P.O. (2016) The Polycomb Group Protein Pcgf1 Is Dispensable in Zebrafish but Involved in Early Growth and Aging. PLoS One. 11:e0158700
- Le Faou, P., Völkel, P., and Angrand, P.O. (2011) The zebrafish genes encoding the Polycomb Repressive Complex (PRC) 1. Gene. 475(1):10-21
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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