Gene

nf2a

ID
ZDB-GENE-080722-7
Name
NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor a
Symbol
nf2a Nomenclature History
Previous Names
  • zgc:194620 (1)
  • zgc:194631 (1)
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable actin binding activity and integrin binding activity. Predicted to be involved in several processes, including positive regulation of early endosome to late endosome transport; positive regulation of protein localization to early endosome; and regulation of hippo signaling. Predicted to be located in cytoskeleton and membrane. Predicted to be active in several cellular components, including adherens junction; apical part of cell; and filopodium. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); malignant pleural mesothelioma; meningioma (multiple); neurilemmoma; and vestibular schwannomatosis. Orthologous to human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Yi et al., 2018
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nf2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
vestibular schwannomatosis Alliance Schwannomatosis, somatic 101000
vestibular schwannomatosis Alliance Schwannomatosis, vestibular 101000
Meningioma, NF2-related, somatic 607174
1 - 3 of 3
Associated With nf2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019747 FERM conserved site
Domain IPR000299 FERM domain
Domain IPR011259 Ezrin/radixin/moesin, C-terminal
Domain IPR018979 FERM, N-terminal
Domain IPR018980 FERM, C-terminal PH-like domain
1 - 5 of 16 Show all
Domain Details Per Protein
Protein Additional Resources Length Band 4.1 domain ERM family, FERM domain C-lobe Ezrin/radixin/moesin Ezrin/radixin/moesin, alpha-helical domain Ezrin/radixin/moesin, C-terminal Ezrin/radixin/moesin-like FERM/acyl-CoA-binding protein superfamily FERM central domain FERM conserved site FERM, C-terminal PH-like domain FERM domain FERM, N-terminal FERM superfamily, second domain Moesin tail domain superfamily PH-like domain superfamily Ubiquitin-like domain superfamily
UniProtKB:B3DGL5 InterPro 593
UniProtKB:A0AB32TRM0 InterPro 592
UniProtKB:A0AB32TTP7 InterPro 449
1 - 3 of 3
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA nf2a-201 (1)
Ensembl
Ensembl 2,152 nt
ZFIN BLAST
mRNA nf2a-202 (1)
Ensembl
Ensembl 6,173 nt
ZFIN BLAST
mRNA nf2a-203 (1)
Ensembl
Ensembl 5,787 nt
ZFIN BLAST
mRNA nf2a-204 (1)
Ensembl
Ensembl 5,758 nt
ZFIN BLAST
1 - 4 of 4
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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