Gene

nfixa

ID

ZDB-GENE-080722-15

Name

nuclear factor I/Xa

Symbol

nfixa Nomenclature History

Previous Names

nfix

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in skeletal muscle fiber development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Marshall-Smith syndrome and Sotos syndrome. Is expressed in central nervous system; muscle; notochord; paraxial mesoderm; and somite. Orthologous to human NFIX (nuclear factor I X).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nfixa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Marshall-Smith syndrome	Alliance	Marshall-Smith syndrome	602535
Sotos syndrome 2	Alliance	Malan syndrome	614753

Associated With nfixa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019739	CTF transcription factor/nuclear factor 1, conserved site
Domain	IPR003619	MAD homology 1, Dwarfin-type
Domain	IPR019548	CTF transcription factor/nuclear factor 1, N-terminal
Domain	IPR020604	CTF transcription factor/nuclear factor 1, DNA-binding domain
Family	IPR000647	CTF transcription factor/nuclear factor 1

Domain Details Per Protein

Protein	Length	CTF transcription factor/nuclear factor 1	CTF transcription factor/nuclear factor 1, conserved site	CTF transcription factor/nuclear factor 1, DNA-binding domain	CTF transcription factor/nuclear factor 1, N-terminal	MAD homology 1, Dwarfin-type
UniProtKB:A0A8M9Q7B4 InterPro	224
UniProtKB:A0A8M9QGH8 InterPro	196
UniProtKB:A0A8M9PNC5 InterPro	246
UniProtKB:A0A8M9PNC9 InterPro	202
UniProtKB:A0A8M9Q7B7 InterPro	204
UniProtKB:A0A8M9QGG6 InterPro	245

Transcripts

Genome Browsers

UCSC

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	nfixa-201 (1) Ensembl	Havana	1764 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations