Gene
add2
- ID
- ZDB-GENE-080718-4
- Name
- adducin 2 (beta)
- Symbol
- add2 Nomenclature History
- Previous Names
-
- si:dkey-202n14.5 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Predicted to be involved in barbed-end actin filament capping. Predicted to be active in cytoskeleton; plasma membrane; and postsynaptic density. Is expressed in head. Human ortholog(s) of this gene implicated in IgA glomerulonephritis and hypertension. Orthologous to human ADD2 (adducin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la029056Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa13879 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa20359 | Allele with one point mutation | Unknown | Unknown | ENU | |
sa31418 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 4 of 4
Show
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Aldolase class II Adducin subfamily | Class II aldolase/adducin N-terminal | Class II aldolase/adducin N-terminal domain superfamily |
---|---|---|---|---|---|
UniProtKB:A0A8M9PKT7 | InterPro | 568 | |||
UniProtKB:A0A8M6Z6F4 | InterPro | 560 | |||
UniProtKB:A0A8M3B9E6 | InterPro | 668 | |||
UniProtKB:F1QTE3 | InterPro | 669 | |||
UniProtKB:A0A8M3B285 | InterPro | 592 |
1 - 5 of 7 Show all
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-367H4 | ZFIN Curated Data | |
Contained in | BAC | DKEY-202N14 | ZFIN Curated Data | |
Contained in | Fosmid | CH1073-416J2 | ZFIN Curated Data | |
Has Artifact | EST | fk54d07 |
1 - 4 of 4
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001365434 (1) | 6101 nt | ||
Genomic | GenBank:BX322550 (1) | 158410 nt | ||
Polypeptide | UniProtKB:F1QTE3 (1) | 669 aa |
- Tuschl, K., White, R.J., Trivedi, C., Valdivia, L.E., Niklaus, S., Bianco, I.H., Dadswell, C., González-Méndez, R., Sealy, I.M., Neuhauss, S.C.F., Houart, C., Rihel, J., Wilson, S.W., Busch-Nentwich, E.M. (2022) Loss of slc39a14 causes simultaneous manganese hypersensitivity and deficiency in zebrafish. Disease models & mechanisms. 15(6)
- Moore, C., Richens, J.L., Hough, Y., Ucanok, D., Malla, S., Sang, F., Chen, Y., Elworthy, S., Wilkinson, R.N., Gering, M. (2018) Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Blood advances. 2:2589-2606
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Tang, V., Cofer, Z.C., Cui, S., Sapp, V., Loomes, K.M., Matthews, R.P. (2016) Loss of a Candidate Biliary Atresia Susceptibility Gene, add3a, Causes Biliary Developmental Defects in Zebrafish. Journal of pediatric gastroenterology and nutrition. 63(5):524-530
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ge, L., Zhang, R.P., Wan, F., Guo, D.Y., Wang, P., Xiang, L.X., and Shao, J.Z. (2014) TET2 Plays an Essential Role in Erythropoiesis by Regulating Lineage-Specific Genes via DNA Oxidative Demethylation in a Zebrafish Model. Molecular and cellular biology. 34(6):989-1002
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wotton, K.R., Weierud, F.K., Dietrich, S., and Lewis, K.E. (2008) Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates. BMC Evolutionary Biology. 8:171
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
1 - 9 of 9
Show