Gene

kmt2bb

ID
ZDB-GENE-080521-1
Name
lysine (K)-specific methyltransferase 2Bb
Symbol
kmt2bb Nomenclature History
Previous Names
  • mll4b
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have histone methyltransferase activity (H3-K4 specific). Predicted to be involved in histone H3-K4 methylation and positive regulation of transcription, DNA-templated. Predicted to localize to histone methyltransferase complex. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; dystonia; and hepatocellular carcinoma. Orthologous to human KMT2B (lysine methyltransferase 2B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Sun et al., 2008
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kmt2bb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
dystonia 28 childhood-onset Alliance Dystonia 28, childhood-onset 617284
Intellectual developmental disorder, autosomal dominant 68 619934
Associated With kmt2bb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001214 SET domain
Domain IPR001965 Zinc finger, PHD-type
Domain IPR002857 Zinc finger, CXXC-type
Domain IPR003616 Post-SET domain
Domain IPR019787 Zinc finger, PHD-finger
Domain IPR034732 Extended PHD (ePHD) domain
Domain IPR047219 Histone-lysine N-methyltransferase 2A/2B, SET domain
Homologous_superfamily IPR011011 Zinc finger, FYVE/PHD-type
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR036427 Bromodomain-like superfamily
Homologous_superfamily IPR046341 SET domain superfamily
Domain Details Per Protein
Protein Length Bromodomain-like superfamily Extended PHD (ePHD) domain Histone-lysine N-methyltransferase 2A/2B, SET domain Post-SET domain SET domain SET domain superfamily Zinc finger, CXXC-type Zinc finger, FYVE/PHD-type Zinc finger, PHD-finger Zinc finger, PHD-type Zinc finger, RING/FYVE/PHD-type
UniProtKB:F8W580 3772
UniProtKB:A0A8M3AT01 3771
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations