ZFIN is now using GRCz12tu for Genomic Data
Gene
nsd1a
- ID
- ZDB-GENE-080519-3
- Name
- nuclear receptor binding SET domain protein 1a
- Symbol
- nsd1a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable histone H3K36 methyltransferase activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in Sotos syndrome; Sotos syndrome 1; acute myeloid leukemia; microcephaly; and neuroblastoma. Orthologous to human NSD1 (nuclear receptor binding SET domain protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sun et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Calvird et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Sotos syndrome 1 | Alliance | Sotos syndrome | 117550 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019786 | Zinc finger, PHD-type, conserved site |
| Domain | IPR000313 | PWWP domain |
| Domain | IPR001214 | SET domain |
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR003616 | Post-SET domain |
| Domain | IPR006560 | AWS domain |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR041306 | NSD, Cys-His rich domain |
| Domain | IPR047426 | Histone-lysine N-methyltransferase NSD1 / NSD2, first PHD finger |
| Domain | IPR047429 | Nuclear receptor-binding SET domain-containing protein 1, third PHD finger |
| Domain | IPR047430 | Nuclear receptor-binding SET domain-containing protein 1, fourth PHD finger |
| Domain | IPR047432 | Nuclear receptor-binding SET domain-containing protein 1, fifth PHD finger |
| Domain | IPR055197 | Histone-lysine N-methyltransferase NSD-like, variant PHD zinc finger |
| Domain | IPR055198 | Histone-lysine N-methyltransferase NSD-like, PHD zinc finger |
| Domain | IPR059153 | Histone-lysine N-methyltransferase NSD-like, PHD zinc finger 1 |
| Family | IPR050777 | SET2 Histone-Lysine N-Methyltransferase |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR046341 | SET domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | AWS domain | Histone-lysine N-methyltransferase NSD1 / NSD2, first PHD finger | Histone-lysine N-methyltransferase NSD-like, PHD zinc finger | Histone-lysine N-methyltransferase NSD-like, PHD zinc finger 1 | Histone-lysine N-methyltransferase NSD-like, variant PHD zinc finger | NSD, Cys-His rich domain | Nuclear receptor-binding SET domain-containing protein 1, fifth PHD finger | Nuclear receptor-binding SET domain-containing protein 1, fourth PHD finger | Nuclear receptor-binding SET domain-containing protein 1, third PHD finger | Post-SET domain | PWWP domain | SET2 Histone-Lysine N-Methyltransferase | SET domain | SET domain superfamily | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QA79 | InterPro | 2055 | |||||||||||||||||||
| UniProtKB:A0AC58H8T3 | InterPro | 2053 | |||||||||||||||||||
| UniProtKB:A0ACD6B642 | InterPro | 2053 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers