Gene

nr0b2a

ID
ZDB-GENE-080403-1
Name
nuclear receptor subfamily 0, group B, member 2a
Symbol
nr0b2a Nomenclature History
Previous Names
  • NR0B2-A (1)
  • nr0b2a (1)
  • gb:bc058069
  • SHP-A (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have transcription corepressor activity and transcription factor binding activity. Predicted to be involved in circadian rhythm; negative regulation of DNA-binding transcription factor activity; and negative regulation of transcription by RNA polymerase II. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Is expressed in heart and yolk syncytial layer. Orthologous to human NR0B2 (nuclear receptor subfamily 0 group B member 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nr0b2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
obesity Alliance Obesity, mild, early-onset 601665
Associated With nr0b2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Family IPR001723 Nuclear hormone receptor
Family IPR033544 Nuclear receptor subfamily 0 group B member 1/2
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Nuclear receptor subfamily 0 group B member 1/2
UniProtKB:F8W3I2 248
UniProtKB:Q6PEG7 265
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations