Gene
ugt1a7
- ID
- ZDB-GENE-080227-6
- Name
- UDP glucuronosyltransferase 1 family, polypeptide A7
- Symbol
- ugt1a7 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables glucuronosyltransferase activity. Predicted to be located in endoplasmic reticulum membrane. Is expressed in gill and intestine. Human ortholog(s) of this gene implicated in several diseases, including bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; female reproductive organ cancer (multiple); and hepatitis B. Orthologous to human UGT1A1 (UDP glucuronosyltransferase family 1 member A1) and UGT1A5 (UDP glucuronosyltransferase family 1 member A5).
- Genome Resources
-
- Alliance (1)
- Gene:100384891 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wang et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | UDP-glucuronosyl/UDP-glucosyltransferase | UDP-glycosyltransferase | UDP-glycosyltransferase family, conserved site |
|---|---|---|---|---|---|
| UniProtKB:F1R251 | InterPro | 305 | |||
| UniProtKB:D3XD57 | InterPro | 305 | |||
| UniProtKB:D3XD58 | InterPro | 527 | |||
| UniProtKB:E9QF86 | InterPro | 520 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001177334 (1) | 1757 nt | ||
| Genomic | GenBank:AL954329 (1) | 194284 nt | ||
| Polypeptide | UniProtKB:D3XD58 (2) | 527 aa |
- Comparative Orthology
- Alliance
- Christen, V., Fent, K. (2014) Tissue-, sex- and development-specific transcription profiles of eight UDP-glucuronosyltransferase genes in zebrafish (Danio rerio) and their regulation by activator of aryl hydrocarbon receptor. Aquatic toxicology (Amsterdam, Netherlands). 150:93-102
- Wang, Y., Huang, H., Wu, Q. (2014) Characterization of the Zebrafish Ugt Repertoire Reveals a New Class of Drug-metabolizing UDP Glucuronosyltransferases. Molecular pharmacology. 86(1):62-75
- Liu, Y., Wang, J., Fang, X., Zhang, H., and Dai, J. (2011) The thyroid-disrupting effects of long-term perfluorononanoate exposure on zebrafish (Danio rerio). Ecotoxicology (London, England). 20(1):47-55
- Huang, H., and Wu, Q. (2010) Cloning and comparative analyses of the zebrafish ugt repertoire reveal its evolutionary diversity. PLoS One. 5(2):e9144
- Li, C., and Wu, Q. (2007) Adaptive evolution of multiple-variable exons and structural diversity of drug-metabolizing enzymes. BMC Evolutionary Biology. 7(1):69
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