ZFIN is now using GRCz12tu for Genomic Data
Gene
slc9a5
- ID
- ZDB-GENE-080225-43
- Name
- solute carrier family 9 member A5
- Symbol
- slc9a5 Nomenclature History
- Previous Names
-
- nhe5 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to act upstream of or within proton transmembrane transport; regulation of pH; and sodium ion transport. Predicted to be located in recycling endosome membrane. Predicted to be active in plasma membrane. Is expressed in brain and gill. Human ortholog(s) of this gene implicated in end stage renal disease. Orthologous to human SLC9A5 (solute carrier family 9 member A5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Yan et al., 2007
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cation/H+ exchanger, CPA1 family | Cation/H+ exchanger, transmembrane domain | Na+/H+ exchanger | Na+/H+ exchanger, isoforms 3/5 |
|---|---|---|---|---|---|---|
| UniProtKB:A9XPA2 | InterPro | 970 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc9a5-201
(1)
|
Ensembl | 4,528 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-262A21 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001113472 (1) | 4439 nt | ||
| Genomic | GenBank:AL954769 (1) | 145555 nt | ||
| Polypeptide | UniProtKB:A9XPA2 (1) | 970 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Orosz, F. (2015) On the tubulin polymerization promoting proteins of zebrafish. Biochemical and Biophysical Research Communications. 457(3):267-72
- Yan, J.J., Chou, M.Y., Kaneko, T., and Hwang, P.P. (2007) Gene expression of Na+/H+ exchanger in zebrafish H+-ATPase-rich cells during acclimation to low-Na+ and acidic environments. American journal of physiology. Cell physiology. 293(6):C184-C1823
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