ZFIN is now using GRCz12tu for Genomic Data
Gene
asmt
- ID
- ZDB-GENE-080220-43
- Name
- acetylserotonin O-methyltransferase
- Symbol
- asmt Nomenclature History
- Previous Names
-
- hiomt (1)
- zgc:171885
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable acetylserotonin O-methyltransferase activity. Predicted to be involved in melatonin biosynthetic process and methylation. Is expressed in brain; epiphysis; eye; and ovary. Orthologous to human ASMT (acetylserotonin O-methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Aranda-Martínez et al., 2025
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001077 | O-methyltransferase domain |
| Family | IPR016461 | O-methyltransferase COMT-type |
| Homologous_superfamily | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | O-methyltransferase COMT-type | O-methyltransferase domain | S-adenosyl-L-methionine-dependent methyltransferase superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A8KBA2 | InterPro | 344 | |||||
| UniProtKB:A0A0R4ITX8 | InterPro | 344 | |||||
| UniProtKB:A0A8M3B5X1 | InterPro | 346 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-19K12 | ||
| Encodes | cDNA | MGC:171885 | ZFIN Curated Data |
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- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001114909 (1) | 1293 nt | ||
| Genomic | GenBank:FP245397 (2) | 153002 nt | ||
| Polypeptide | UniProtKB:A0A8M3B5X1 (1) | 346 aa |
- Aranda-Martínez, P., Fernández-Martínez, J., Díaz-Casado, M.E., Ramírez-Casas, Y., Martín-Estebané, M., López-Rodríguez, A., Escames, G., Acuña-Castroviejo, D. (2025) Lack of asmt1 or asmt2 Yields Different Phenotypes and Malformations in Larvae to Adult Zebrafish. International Journal of Molecular Sciences. 26:
- Lee, J.H., Hwang, S.J., Ham, S.L., Kim, J., Bang, H.J., Park, J.S., Jang, H.H., Kim, T.Y., Park, J.W., Seo, Y.R., Kim, B.S., Kim, G.S., Lee, H.J., Kim, C.S. (2024) Gut Bacterial Metabolites from Tryptophan and Phenylalanine Induce Melatonin Synthesis and Extend Sleep Duration in Mice. ACS omega. 9:438754388343875-43883
- Dekens, M.P.S., Fontinha, B.M., Gallach, M., Pflügler, S., Tessmar-Raible, K. (2022) Melanopsin elevates locomotor activity during the wake state of the diurnal zebrafish. EMBO reports. 23(5):e51528
- Khan, Z.A., Yumnamcha, T., Rajiv, C., Devi, H.S., Mondal, G., Dharmajyoti Devi, S., Bharali, R., Chattoraj, A. (2016) Melatonin Biosynthesizing Enzyme Genes and Clock Genes in Ovary and Whole Brain of Zebrafish (Danio rerio): Differential Expression and a Possible Interplay. General and comparative endocrinology. 233:16-31
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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