Gene

fbxo6.3

ID

ZDB-GENE-080218-15

Name

F-box protein 6, tandem duplicate 3

Symbol

fbxo6.3 Nomenclature History

Previous Names

fbxo44.6
si:rp71-1k13.8
zgc:173570

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and glycoprotein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human FBXO44 (F-box protein 44) and FBXO6 (F-box protein 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

No data available

Sequence Targeting Reagents

No data available

Human Disease

Associated With fbxo6.3 Human Ortholog

No data available

Associated With fbxo6.3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001810	F-box domain
Domain	IPR007397	F-box associated (FBA) domain
Family	IPR039752	F-box only protein
Homologous_superfamily	IPR008979	Galactose-binding-like domain superfamily
Homologous_superfamily	IPR036047	F-box-like domain superfamily

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Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M6YVW7	InterPro	252
UniProtKB:A8KBJ9	InterPro	282
UniProtKB:A0A8M6Z3T2	InterPro	167
UniProtKB:A0A8M6YVA4	InterPro	197

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 23

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	zgc:173570-201 (1) Ensembl	Ensembl		1,616 nt	Select Tool ZFIN BLAST
mRNA	zgc:173570-202 (1) Ensembl	Ensembl		168 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	RP71-1K13	AL732515	ZFIN Curated Data
Encodes	cDNA	MGC:173570	BC154142	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001111202 (1)	1645 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:AL732515 (1)	154426 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A8KBJ9 (1)	282 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl
Note: This gene is in a cluster of ten fbxo6/fbxo44 genes and relationships are difficult to discern. Current analysis (January 2021) suggests three fbxo44 and fbxo6 gene pairs followed by four additional fbxo44 genes.

Species	Symbol	Chromosome	Accession #	Evidence
Mouse	Fbxo6	4	Ensembl:ENSMUSG00000055401 Gene:50762 MGI:1354743	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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