Gene
myrf
- ID
- ZDB-GENE-080204-57
- Name
- myelin regulatory factor
- Symbol
- myrf Nomenclature History
- Previous Names
-
- c11orf9 (1)
- zgc:172183
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Acts upstream of or within central nervous system myelination and positive regulation of myelination. Predicted to be located in cytoplasm; endomembrane system; and membrane. Predicted to be active in endoplasmic reticulum membrane and nucleus. Is expressed in oligodendrocyte. Used to study eye disease. Human ortholog(s) of this gene implicated in cerebral infarction; congenital diaphragmatic hernia; hyperopia; nanophthalmos; and primary angle-closure glaucoma. Orthologous to human MYRF (myelin regulatory factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-myrf | (2) | |
MO1-myrf | N/A | Xiao et al., 2019 |
1 - 2 of 2
Show
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
nanophthalmos | Alliance | Nanophthalmos 1 | 600165 |
Cardiac-urogenital syndrome | 618280 | ||
Encephalitis/encephalopathy, mild, with reversible myelin vacuolization | 618113 |
1 - 3 of 3
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
eye disease | AB + MO1-myrf | standard conditions | Xiao et al., 2019 |
1 - 1 of 1
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR024061 | NDT80 DNA-binding domain |
Domain | IPR025719 | Myelin gene regulatory factor C-terminal domain 2 |
Domain | IPR026932 | Myelin gene regulatory factor, ICA domain |
Domain | IPR030392 | Intramolecular chaperone auto-processing domain |
Family | IPR051577 | Myelin Regulatory Factor-like |
1 - 5 of 7 Show all
Domain Details Per Protein
Protein | Additional Resources | Length | Intramolecular chaperone auto-processing domain | Myelin gene regulatory factor C-terminal domain 2 | Myelin gene regulatory factor, ICA domain | Myelin Regulatory Factor-like | NDT80 DNA-binding domain | NDT80 DNA-binding domain superfamily | p53-like transcription factor, DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M3ANV6 | InterPro | 1027 | |||||||
UniProtKB:A0A8M9P6L9 | InterPro | 1009 | |||||||
UniProtKB:A0A8M9PV81 | InterPro | 1034 | |||||||
UniProtKB:A0A8M9PYN2 | InterPro | 1036 | |||||||
UniProtKB:A0A8M3AWA7 | InterPro | 1037 |
1 - 5 of 6 Show all
Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(myrf:GAL4-VP16,myl7:EGFP) |
|
| 1 | Treichel et al., 2018 |
1 - 1 of 1
Show
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-70E5 | ZFIN Curated Data | |
Contained in | BAC | CH211-247I17 | ZFIN Curated Data | |
Contained in | Fosmid | CH1073-89B12 | ZFIN Curated Data | |
Encodes | cDNA | MGC:172183 | ZFIN Curated Data |
1 - 4 of 4
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001201392 (1) | 2073 nt | ||
Genomic | GenBank:CU855758 (2) | 112125 nt | ||
Polypeptide | UniProtKB:A0A8M3AWA7 (1) | 1037 aa |
- Zhang, T., Alonzo, I., Stubben, C., Geng, Y., Herdman, C., Chandler, N., Doane, K.P., Pluimer, B.R., Trauger, S.A., Peterson, R.T. (2023) A zebrafish model of Combined Saposin Deficiency identifies acid sphingomyelinase as a potential therapeutic target. Disease models & mechanisms. 16(7):
- Benardais, K., Ornelas, I.M., Fauveau, M., Brown, T.L., Finseth, L.T., Panic, R., Deboux, C., Macklin, W.B., Wood, T.L., Nait-Oumesmar, B. (2022) p70S6 kinase regulates oligodendrocyte differentiation and is active in remyelinating lesions. Brain communications. 4:fcac025
- Almeida, R.G., Williamson, J.M., Madden, M.E., Early, J.J., Voas, M.G., Talbot, W.S., Bianco, I.H., Lyons, D.A. (2021) Myelination induces axonal hotspots of synaptic vesicle fusion that promote sheath growth. Current biology : CB. 31(17):3743-3754.e5
- Kearns, C.A., Walker, M., Ravanelli, A.M., Scott, K., Arzbecker, M.R., Appel, B. (2021) Zebrafish spinal cord oligodendrocyte formation requires boc function. Genetics. 218(4):
- Madden, M.E., Suminaite, D., Ortiz, E., Early, J.E., Koudelka, S., Livesey, M.R., Bianco, I.H., Granato, M., Lyons, D.A. (2021) Central nervous system hypomyelination disrupts axonal conduction and behaviour in larval zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(44):9099-9111
- Scott, K., O'Rourke, R., Winkler, C.C., Kearns, C.A., Appel, B. (2021) Temporal single-cell transcriptomes of zebrafish spinal cord pMN progenitors reveal distinct neuronal and glial progenitor populations. Developmental Biology. 479:37-50
- Hughes, A.N., Appel, B. (2020) Microglia phagocytose myelin sheaths to modify developmental myelination. Nature Neuroscience. 23(9):1055-1066
- Marisca, R., Hoche, T., Agirre, E., Hoodless, L.J., Barkey, W., Auer, F., Castelo-Branco, G., Czopka, T. (2020) Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation. Nature Neuroscience. 23(3):363-374
- Scott, K., O'Rourke, R., Gillen, A., Appel, B. (2020) Prdm8 regulates pMN progenitor specification for motor neuron and oligodendrocyte fates by modulating Shh signaling response. Development (Cambridge, England). 147(16):
- Klingseisen, A., Ristoiu, A.M., Kegel, L., Sherman, D.L., Rubio-Brotons, M., Almeida, R.G., Koudelka, S., Benito-Kwiecinski, S.K., Poole, R.J., Brophy, P.J., Lyons, D.A. (2019) Oligodendrocyte Neurofascin Independently Regulates Both Myelin Targeting and Sheath Growth in the CNS. Developmental Cell. 51(6):730-744.e6
1 - 10 of 15
Show