Gene

myrf

ID
ZDB-GENE-080204-57
Name
myelin regulatory factor
Symbol
myrf Nomenclature History
Previous Names
  • c11orf9 (1)
  • zgc:172183
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Acts upstream of or within central nervous system myelination and positive regulation of myelination. Predicted to be located in cytoplasm; endomembrane system; and membrane. Predicted to be active in endoplasmic reticulum membrane and nucleus. Is expressed in oligodendrocyte. Used to study eye disease. Human ortholog(s) of this gene implicated in cerebral infarction; congenital diaphragmatic hernia; hyperopia; nanophthalmos; and primary angle-closure glaucoma. Orthologous to human MYRF (myelin regulatory factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa15620Allele with one point mutationUnknownPremature StopENU
sa44219Allele with one point mutationUnknownPremature StopENU
ue70Allele with one delinsExon 2UnknownCRISPR
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-myrf (2)
MO1-myrfN/AXiao et al., 2019
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Human Disease
Associated With myrf Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
nanophthalmos Alliance Nanophthalmos 1 600165
Cardiac-urogenital syndrome 618280
Encephalitis/encephalopathy, mild, with reversible myelin vacuolization 618113
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Associated With myrf Via Experimental Models
Human Disease Fish Conditions Citations
eye disease AB + MO1-myrf standard conditions Xiao et al., 2019
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Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR024061 NDT80 DNA-binding domain
Domain IPR025719 Myelin gene regulatory factor C-terminal domain 2
Domain IPR026932 Myelin gene regulatory factor, ICA domain
Domain IPR030392 Intramolecular chaperone auto-processing domain
Family IPR051577 Myelin Regulatory Factor-like
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Domain Details Per Protein
Protein Additional Resources Length Intramolecular chaperone auto-processing domain Myelin gene regulatory factor C-terminal domain 2 Myelin gene regulatory factor, ICA domain Myelin Regulatory Factor-like NDT80 DNA-binding domain NDT80 DNA-binding domain superfamily p53-like transcription factor, DNA-binding domain superfamily
UniProtKB:A0A8M3ANV6 InterPro 1027
UniProtKB:A0A8M9P6L9 InterPro 1009
UniProtKB:A0A8M9PV81 InterPro 1034
UniProtKB:A0A8M9PYN2 InterPro 1036
UniProtKB:A0A8M3AWA7 InterPro 1037
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 25
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA myrf-201 (1) Ensembl 4,844 nt
mRNA myrf-202 (1) Ensembl 2,051 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(myrf:GAL4-VP16,myl7:EGFP)
  • Danio rerio
1Treichel et al., 2018
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-70E5ZFIN Curated Data
Contained inBACCH211-247I17ZFIN Curated Data
Contained inFosmidCH1073-89B12ZFIN Curated Data
EncodescDNAMGC:172183ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanMYRF11
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseMyrf19
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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