Gene

lifrb

ID

ZDB-GENE-080107-2

Name

LIF receptor subunit alpha b

Symbol

lifrb Nomenclature History

Previous Names

si:dkey-120e24.3

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have cytokine binding activity and cytokine receptor activity. Predicted to localize to external side of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in osteochondrodysplasia and primary cutaneous amyloidosis. Is expressed in several structures, including immune system; liver; nervous system; notochord; and otic vesicle. Orthologous to several human genes including LIFR (LIF receptor subunit alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Hanington et al., 2008
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lifrb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Stuve-Wiedemann syndrome/Schwartz-Jampel type 2 syndrome	601559

Associated With lifrb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003529	Long hematopoietin receptor, Gp130 family 2, conserved site
Domain	IPR003961	Fibronectin type III
Domain	IPR040817	Leukemia inhibitory factor receptor, D2 domain
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily