Gene

dnajc6

ID

ZDB-GENE-080104-2

Name

DnaJ (Hsp40) homolog, subfamily C, member 6

Symbol

dnajc6 Nomenclature History

Previous Names

Aux (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have clathrin binding activity. Predicted to be involved in clathrin-dependent endocytosis and synaptic vesicle uncoating. Localizes to cytosol and perinuclear region of cytoplasm. Is expressed in hindbrain; inner ear; neural rod; otic vesicle; and spinal cord. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 19A. Orthologous to human DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Bai et al., 2010

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dnajc6 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Parkinson's disease 19A	Alliance	Parkinson disease 19a, juvenile-onset	615528
Parkinson's disease 19A	Alliance	Parkinson disease 19b, early-onset	615528

Associated With dnajc6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001623	DnaJ domain
Domain	IPR014020	Tensin phosphatase, C2 domain
Domain	IPR029023	Tensin-type phosphatase domain
Homologous_superfamily	IPR029021	Protein-tyrosine phosphatase-like
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR036869	Chaperone J-domain superfamily

Domain Details Per Protein

Protein	Length	C2 domain superfamily	Chaperone J-domain superfamily	DnaJ domain	Protein-tyrosine phosphatase-like	Tensin phosphatase, C2 domain	Tensin-type phosphatase domain
UniProtKB:A0A2R8QAE5 InterPro	890
UniProtKB:A0A2R8PY97 InterPro	882
UniProtKB:A0A2R8Q7J4 InterPro	870
UniProtKB:A0A2R8PY05 InterPro	867
UniProtKB:A0A2R8QQF4 InterPro	899
UniProtKB:A0A2R8QDD1 InterPro	871
UniProtKB:A0A2R8QIA5 InterPro	913
UniProtKB:E7F8A0 InterPro	903

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Length (nt)	Analysis
mRNA	dnajc6-201 (1) Ensembl	7250 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	dnajc6-002 (1) Ensembl	560 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations