Gene

dnajc6

ID
ZDB-GENE-080104-2
Name
DnaJ (Hsp40) homolog, subfamily C, member 6
Symbol
dnajc6 Nomenclature History
Previous Names
  • Aux (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have clathrin binding activity. Predicted to be involved in clathrin-dependent endocytosis and synaptic vesicle uncoating. Localizes to cytosol and perinuclear region of cytoplasm. Is expressed in hindbrain; inner ear; neural rod; otic vesicle; and spinal cord. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 19A. Orthologous to human DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Bai et al., 2010
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dnajc6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Parkinson's disease 19A Alliance Parkinson disease 19a, juvenile-onset 615528
Parkinson's disease 19A Alliance Parkinson disease 19b, early-onset 615528
Associated With dnajc6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001623 DnaJ domain
Domain IPR014020 Tensin phosphatase, C2 domain
Domain IPR029023 Tensin-type phosphatase domain
Homologous_superfamily IPR029021 Protein-tyrosine phosphatase-like
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR036869 Chaperone J-domain superfamily
Domain Details Per Protein
Protein Length C2 domain superfamily Chaperone J-domain superfamily DnaJ domain Protein-tyrosine phosphatase-like Tensin phosphatase, C2 domain Tensin-type phosphatase domain
UniProtKB:A0A2R8QAE5 890
UniProtKB:A0A2R8PY97 882
UniProtKB:A0A2R8Q7J4 870
UniProtKB:A0A2R8PY05 867
UniProtKB:A0A2R8QQF4 899
UniProtKB:A0A2R8QDD1 871
UniProtKB:A0A2R8QIA5 913
UniProtKB:E7F8A0 903
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations