Gene
dnajc6
- ID
- ZDB-GENE-080104-2
- Name
- DnaJ (Hsp40) homolog, subfamily C, member 6
- Symbol
- dnajc6 Nomenclature History
- Previous Names
-
- Aux (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have clathrin binding activity. Predicted to be involved in clathrin-dependent endocytosis and synaptic vesicle uncoating. Localizes to cytosol and perinuclear region of cytoplasm. Is expressed in hindbrain; inner ear; neural rod; otic vesicle; and spinal cord. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 19A. Orthologous to human DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Bai et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Parkinson's disease 19A | Alliance | Parkinson disease 19a, juvenile-onset | 615528 |
Parkinson's disease 19A | Alliance | Parkinson disease 19b, early-onset | 615528 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001623 | DnaJ domain |
Domain | IPR014020 | Tensin phosphatase, C2 domain |
Domain | IPR029023 | Tensin-type phosphatase domain |
Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
Homologous_superfamily | IPR035892 | C2 domain superfamily |
Homologous_superfamily | IPR036869 | Chaperone J-domain superfamily |
Domain Details Per Protein
Protein | Length | C2 domain superfamily | Chaperone J-domain superfamily | DnaJ domain | Protein-tyrosine phosphatase-like | Tensin phosphatase, C2 domain | Tensin-type phosphatase domain |
---|---|---|---|---|---|---|---|
UniProtKB:A0A2R8QAE5
|
890 | ||||||
UniProtKB:A0A2R8PY97
|
882 | ||||||
UniProtKB:A0A2R8Q7J4
|
870 | ||||||
UniProtKB:A0A2R8PY05
|
867 | ||||||
UniProtKB:A0A2R8QQF4
|
899 | ||||||
UniProtKB:A0A2R8QDD1
|
871 | ||||||
UniProtKB:A0A2R8QIA5
|
913 | ||||||
UniProtKB:E7F8A0
|
903 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
dnajc6-201
(1)
|
7250 nt | |
ncRNA |
dnajc6-002
(1)
|
560 nt |
Interactions and Pathways
No data available
Plasmids
No data available