Gene
arhgap45b
- ID
- ZDB-GENE-071213-2
- Name
- Rho GTPase activating protein 45b
- Symbol
- arhgap45b Nomenclature History
- Previous Names
-
- arhgap45
- hmha1
- hmha1b
- si:ch73-243b8.4
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be located in cytosol. Predicted to be active in membrane. Orthologous to human ARHGAP45 (Rho GTPase activating protein 45).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Gomez et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028411Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa24143 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37489 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45767 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 4 of 4
Show
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AH/BAR domain superfamily | C1-like domain superfamily | F-BAR domain | FCH domain | GMIP/FCHO2-like, FCH domain | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Rho GTPase-activating | Rho GTPase-activating protein domain | Rho GTPase activation protein |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BHU6 | InterPro | 1136 | |||||||||
| UniProtKB:A0A8M2BI97 | InterPro | 1134 | |||||||||
| UniProtKB:A0A8M2BHV5 | InterPro | 1135 | |||||||||
| UniProtKB:A0A8M2BHU4 | InterPro | 1135 | |||||||||
| UniProtKB:A0A8N7USS5 | InterPro | 1127 |
1 - 5 of 7 Show all
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hmha1b-202
(1)
|
Ensembl | 2,728 nt | ||
| mRNA |
si:ch73-243b8.4-201
(1)
|
Ensembl | 1,483 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-243B8 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005170513 (1) | 4419 nt | ||
| Genomic | GenBank:CU695074 (1) | 101593 nt | ||
| Polypeptide | UniProtKB:A0A8M2BHU6 (1) | 1136 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Gomez, G., Lee, J.H., Veldman, M.B., Lu, J., Xiao, X., and Lin, S. (2012) Identification of Vascular and Hematopoietic Genes Downstream of etsrp by Deep Sequencing in Zebrafish. PLoS One. 7(3):e31658
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
1 - 4 of 4
Show