Gene

shmt2

ID
ZDB-GENE-071213-1
Name
serine hydroxymethyltransferase 2 (mitochondrial)
Symbol
shmt2 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Exhibits glycine hydroxymethyltransferase activity and pyridoxal phosphate binding activity. Predicted to be involved in several processes, including carboxylic acid metabolic process; cellular response to tetrahydrofolate; and protein homotetramerization. Localizes to mitochondrion. Is expressed in digestive system; heart; muscle; nervous system; and pleuroperitoneal region. Orthologous to human SHMT2 (serine hydroxymethyltransferase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Thyme et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With shmt2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities 619121
Associated With shmt2 Via Experimental Models
Human Disease Fish Conditions Citations
schizophrenia shmt2a329/a329 standard conditions Thyme et al., 2019
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR039429 Serine hydroxymethyltransferase-like domain
Family IPR001085 Serine hydroxymethyltransferase
Homologous_superfamily IPR015421 Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily IPR015422 Pyridoxal phosphate-dependent transferase, small domain
Homologous_superfamily IPR015424 Pyridoxal phosphate-dependent transferase
Domain Details Per Protein
Protein Length Pyridoxal phosphate-dependent transferase Pyridoxal phosphate-dependent transferase, major domain Pyridoxal phosphate-dependent transferase, small domain Serine hydroxymethyltransferase Serine hydroxymethyltransferase-like domain
UniProtKB:A9LDD9 492
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations