Gene

top3a

ID
ZDB-GENE-071212-2
Name
DNA topoisomerase III alpha
Symbol
top3a Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have DNA topoisomerase activity. Predicted to be involved in DNA topological change. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5. Orthologous to human TOP3A (DNA topoisomerase III alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Mönnich et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With top3a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5 Alliance Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 5 618098
Microcephaly, growth restriction, and increased sister chromatid exchange 2 618097
Associated With top3a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR023406 DNA topoisomerase, type IA, active site
Domain IPR003601 DNA topoisomerase, type IA, domain 2
Domain IPR003602 DNA topoisomerase, type IA, DNA-binding domain
Domain IPR006171 TOPRIM domain
Domain IPR010666 Zinc finger, GRF-type
Domain IPR013497 DNA topoisomerase, type IA, central
Domain IPR013498 DNA topoisomerase, type IA, zn finger
Domain IPR034144 DNA topoisomerase 3-like, TOPRIM domain
Family IPR000380 DNA topoisomerase, type IA
Homologous_superfamily IPR013824 DNA topoisomerase, type IA, central region, subdomain 1
Homologous_superfamily IPR013825 DNA topoisomerase, type IA, central region, subdomain 2
Homologous_superfamily IPR013826 DNA topoisomerase, type IA, central region, subdomain 3
Homologous_superfamily IPR023405 DNA topoisomerase, type IA, core domain
Domain Details Per Protein
Protein Length DNA topoisomerase 3-like, TOPRIM domain DNA topoisomerase, type IA DNA topoisomerase, type IA, active site DNA topoisomerase, type IA, central DNA topoisomerase, type IA, central region, subdomain 1 DNA topoisomerase, type IA, central region, subdomain 2 DNA topoisomerase, type IA, central region, subdomain 3 DNA topoisomerase, type IA, core domain DNA topoisomerase, type IA, DNA-binding domain DNA topoisomerase, type IA, domain 2 DNA topoisomerase, type IA, zn finger TOPRIM domain Zinc finger, GRF-type
UniProtKB:X1WCF3
InterPro
998
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA top3a-201 (1)
Ensembl
Havana 3292 nt
ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA top3a-002 (1)
Ensembl
Havana 447 nt
ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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