ZFIN is now using GRCz12tu for Genomic Data
Gene
nod1
- ID
- ZDB-GENE-071116-9
- Name
- nucleotide-binding oligomerization domain containing 1
- Symbol
- nod1 Nomenclature History
- Previous Names
-
- NLR-A1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable CARD domain binding activity; oligopeptide binding activity; and pattern recognition receptor activity. Acts upstream of or within several processes, including defense response to bacterium; defense response to virus; and hatching behavior. Predicted to be located in basolateral plasma membrane and cytoplasm. Predicted to be part of canonical inflammasome complex. Predicted to be active in cytosol. Is expressed in brain; digestive system; gill; pleuroperitoneal region; and unfertilized egg. Human ortholog(s) of this gene implicated in asthma and atopic dermatitis. Orthologous to human NOD1 (nucleotide binding oligomerization domain containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001315 | CARD domain |
| Domain | IPR007111 | NACHT nucleoside triphosphatase |
| Domain | IPR041075 | NOD1/2, winged helix domain |
| Domain | IPR041267 | NACHT, LRR and PYD domains-containing protein, helical domain HD2 |
| Family | IPR050637 | NLRP family, innate immunity and inflammation regulators |
| Family | IPR051261 | NOD-like receptor |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | CARD domain | Death-like domain superfamily | Leucine-rich repeat | Leucine-rich repeat domain superfamily | NACHT, LRR and PYD domains-containing protein, helical domain HD2 | NACHT nucleoside triphosphatase | NLRP family, innate immunity and inflammation regulators | NOD1/2, winged helix domain | NOD-like receptor | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1RMD1 | InterPro | 940 | ||||||||||
| UniProtKB:A0AB32T621 | InterPro | 912 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance