Gene
tyk2
- ID
- ZDB-GENE-071116-4
- Name
- tyrosine kinase 2
- Symbol
- tyk2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable growth hormone receptor binding activity and non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in cell differentiation; cell surface receptor signaling pathway; and intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoskeleton and membrane. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in immunodeficiency 35. Orthologous to human TYK2 (tyrosine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Gao et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la015241Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa2092 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa5732 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa13280 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa31356 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
immunodeficiency 35 | Alliance | Immunodeficiency 35 | 611521 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Band 4.1 domain | FERM central domain | FERM domain | FERM F1 lobe ubiquitin-like domain | FERM superfamily, second domain | JAK1-3/TYK2, pleckstrin homology-like domain | JAK, FERM F2 lobe domain | Janus Kinase (JAK) | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, non-receptor Jak/Tyk2 | Tyrosine-protein kinase, non-receptor, TYK2, N-terminal |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2BBI7 | InterPro | 1164 | ||||||||||||||||||
UniProtKB:A0A8M3AQW8 | InterPro | 1165 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-66E2 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_003198153 (1) | 4748 nt | ||
Genomic | GenBank:CR354432 (1) | 193960 nt | ||
Polypeptide | UniProtKB:A0A8M3AQW8 (1) | 1165 aa |
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Gao, X., Yuan, Y.Y., Lin, Q.F., Xu, J.C., Wang, W.Q., Qiao, Y.H., Kang, D.Y., Bai, D., Xin, F., Huang, S.S., Qiu, S.W., Guan, L.P., Su, Y., Wang, G.J., Han, M.Y., Jiang, Y., Liu, H.K., Dai, P. (2018) Mutation of IFNLR1, an interferon lambda receptor 1, is associated with autosomal-dominant non-syndromic hearing loss.. Journal of Medical Genetics. 55(5):298-306
- Hou, Q., Gong, R., Liu, X., Mao, H., Xu, X., Liu, D., Dai, Z., Wang, H., Wang, B., Hu, C. (2017) Poly I:C facilitates the phosphorylation of Ctenopharyngodon idellus type I IFN receptor subunits and JAK kinase. Fish & shellfish immunology. 60:13-20
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Liongue, C., O'Sullivan. L.A., Trengove, M.C., and Ward, A.C. (2012) Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. PLoS One. 7(3):e32777
- Stein, C., Caccamo, M., Laird, G., and Leptin, M. (2007) Conservation and divergence of gene families encoding components of innate immune response systems in the zebrafish. Genome biology. 8(11):R251
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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