Gene

tyk2

ID
ZDB-GENE-071116-4
Name
tyrosine kinase 2
Symbol
tyk2 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to enable growth hormone receptor binding activity and non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in cell differentiation; cell surface receptor signaling pathway; and intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoskeleton and membrane. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in immunodeficiency 35. Orthologous to human TYK2 (tyrosine kinase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Gao et al., 2018
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la015241TgTransgenic insertionUnknownUnknownDNA
sa2092Allele with one point mutationUnknownSplice SiteENU
sa5732Allele with one point mutationUnknownSplice SiteENU
sa13280Allele with one point mutationUnknownSplice SiteENU
sa31356Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With tyk2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 35 Alliance Immunodeficiency 35 611521
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Associated With tyk2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000299 FERM domain
Domain IPR000719 Protein kinase domain
Domain IPR000980 SH2 domain
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Domain Details Per Protein
Protein Additional Resources Length Band 4.1 domain FERM central domain FERM domain FERM F1 lobe ubiquitin-like domain FERM superfamily, second domain JAK1-3/TYK2, pleckstrin homology-like domain JAK, FERM F2 lobe domain Janus Kinase (JAK) Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain SH2 domain SH2 domain superfamily Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, non-receptor Jak/Tyk2 Tyrosine-protein kinase, non-receptor, TYK2, N-terminal
UniProtKB:A0A8M2BBI7 InterPro 1164
UniProtKB:A0A8M3AQW8 InterPro 1165
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 3
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA tyk2-201 (1) Ensembl 4,696 nt
mRNA tyk2-202 (1) Ensembl 8,411 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-66E2
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanTYK219
Amino acid sequence comparison (4)
Conserved genome location (synteny) (1)
Phylogenetic tree (1)
MouseTyk29
Conserved genome location (synteny) (1)
Phylogenetic tree (1)
Amino acid sequence comparison (4)
Citations
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