Gene

ikbkb

ID

ZDB-GENE-071115-2

Name

inhibitor of nuclear factor kappa B kinase subunit beta

Symbol

ikbkb Nomenclature History

Previous Names

ikk2 (1)
Ikkb (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Exhibits kinase activity. Predicted to contribute to IkappaB kinase activity. Involved in regulation of cytokinesis and skin development. Predicted to localize to IkappaB kinase complex. Human ortholog(s) of this gene implicated in breast cancer; dermatitis; primary immunodeficiency disease; prostate cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Anelli et al., 2009

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Shen et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ikbkb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency 15A	Alliance	Immunodeficiency 15A	618204
immunodeficiency 15B	Alliance	Immunodeficiency 15B	615592

Associated With ikbkb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Domain	IPR000626	Ubiquitin-like domain
Domain	IPR000719	Protein kinase domain
Domain	IPR041185	IKBKB, scaffold dimerization domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR046375	IKBKB, scaffold dimerization domain superfamily

Domain Details Per Protein

Protein	Length	IKBKB, scaffold dimerization domain	IKBKB, scaffold dimerization domain superfamily	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site	Ubiquitin-like domain	Ubiquitin-like domain superfamily
UniProtKB:A0A8M1NIE6 InterPro	779

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ikbkb-202 (1) Ensembl	Havana	2680 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ikbkb-002 (1) Ensembl	Havana	547 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations