Gene
mfap4.2
- ID
- ZDB-GENE-071004-112
- Name
- microfibril associated protein 4, tandem duplicate 2
- Symbol
- mfap4.2 Nomenclature History
- Previous Names
-
- si:zfos-2330d3.5
- zgc:173915
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in extracellular matrix and extracellular space. Is expressed in female organism and macrophage. Used to study Smith-Magenis syndrome. Orthologous to human MFAP4 (microfibril associated protein 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Ong et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mfap4 | Ong et al., 2020 | |
| CRISPR2-mfap4 | Ong et al., 2020 |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Smith-Magenis syndrome | mfap4.2imb5/imb5 | standard conditions | Ong et al., 2020 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002181 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain |
| Family | IPR050373 | Fibrinogen C-terminal domain-containing protein |
| Homologous_superfamily | IPR014716 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 |
| Homologous_superfamily | IPR036056 | Fibrinogen-like, C-terminal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 | Fibrinogen C-terminal domain-containing protein | Fibrinogen-like, C-terminal |
|---|---|---|---|---|---|---|
| UniProtKB:A8E547 | InterPro | 242 | ||||
| UniProtKB:F1QWC1 | InterPro | 242 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mfap4 (1 of many)-203
(1)
|
Ensembl | 1,007 nt | ||
| mRNA |
mfap4.2-203
(1)
|
Ensembl | 1,006 nt | ||
| mRNA |
zgc:173915-002
(1)
|
Ensembl | 756 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | ZFOS-2330D3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173915 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001109850 (1) | 1035 nt | ||
| Genomic | GenBank:FP017168 (1) | 46247 nt | ||
| Polypeptide | UniProtKB:A8E547 (1) | 242 aa |
- Comparative Orthology
- Alliance
- Leiba, J., Sipka, T., Begon-Pescia, C., Bernardello, M., Tairi, S., Bossi, L., Gonzalez, A.A., Mialhe, X., Gualda, E., Loza-Alvarez, P., Blanc-Potard, A., Lutfalla, G., Nguyen-Chi, M.E. (2024) Dynamics of macrophage polarization support Salmonella persistence in a whole living organism. eLIFE. 13:
- Moyse, B.R., Richardson, R.J. (2020) A Population of Injury-Responsive Lymphoid Cells Expresses mpeg1.1 in the Adult Zebrafish Heart. ImmunoHorizons. 4:464-474
- Ong, S.L.M., de Vos, I.J.H.M., Meroshini, M., Poobalan, Y., Dunn, N.R. (2020) Microfibril-associated glycoprotein 4 (Mfap4) regulates haematopoiesis in zebrafish. Scientific Reports. 10:11801
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Anbalagan, S., Gordon, L., Blechman, J., Matsuoka, R.L., Rajamannar, P., Wircer, E., Biran, J., Reuveny, A., Leshkowitz, D., Stainier, D.Y.R., Levkowitz, G. (2018) Pituicyte Cues Regulate the Development of Permeable Neuro-Vascular Interfaces. Developmental Cell. 47(6):711-726.e5
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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