Gene
scn2b
- ID
- ZDB-GENE-070920-1
- Name
- sodium channel, voltage-gated, type II, beta
- Symbol
- scn2b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable sodium channel regulator activity. Predicted to be involved in cardiac conduction; cardiac muscle cell action potential involved in contraction; and membrane depolarization during cardiac muscle cell action potential. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in plasma membrane. Is expressed in atrium; brain; cardiac ventricle; and eye. Human ortholog(s) of this gene implicated in familial atrial fibrillation. Orthologous to human SCN2B (sodium voltage-gated channel beta subunit 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Chopra et al., 2007
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
familial atrial fibrillation | Alliance | Atrial fibrillation, familial, 14 | 615378 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin V-set domain | Myelin P0 protein-related |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q06W28 | InterPro | 230 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-184G13 | ||
Encodes | cDNA | MGC:194403 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001346412 (1) | 7571 nt | ||
Genomic | GenBank:CU019627 (2) | 39615 nt | ||
Polypeptide | UniProtKB:Q06W28 (1) | 230 aa |
- Tsata, V., Kroehne, V., Reinhardt, S., El-Armouche, A., Brand, M., Wagner, M., Reimer, M.M. (2019) Electrophysiological Properties of Adult Zebrafish Oligodendrocyte Progenitor Cells. Frontiers in Cellular Neuroscience. 13:102
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Baraban, S.C., Dinday, M.T., and Hortopan, G.A. (2013) Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nature communications. 4:2410
- Grayfer, L., and Belosevic, M. (2012) Indentification and molecular characterization of the interleukin-10 receptor 1 of the zebrafish (Danio rerio) and the goldfish (Carassius auratus L.). Developmental and comparative immunology. 36(2):408-17
- Chopra, S.S., Watanabe, H., Zhong, T.P., and Roden, D.M. (2007) Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: Implications for the evolution of electrical signaling in vertebrates. BMC Evolutionary Biology. 7(1):113
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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