Gene
kcnn1a
- ID
- ZDB-GENE-070912-703
- Name
- potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1a
- Symbol
- kcnn1a Nomenclature History
- Previous Names
-
- si:rp71-39b20.3
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable calmodulin binding activity and small conductance calcium-activated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in Z disc and membrane. Predicted to be active in neuron projection; neuronal cell body; and plasma membrane. Is expressed in anterior neural tube; brain; and posterior lateral plate mesoderm. Orthologous to human KCNN1 (potassium calcium-activated channel subfamily N member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Silic et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6838 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11915 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12321 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13213 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19745 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32910 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Calmodulin-binding domain | Potassium channel, calcium-activated, SK | Potassium channel domain | SK, calmodulin-binding domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BIK5 | InterPro | 893 | ||||
| UniProtKB:A0A8M9QNQ2 | InterPro | 896 | ||||
| UniProtKB:A0A8M2BIZ6 | InterPro | 890 | ||||
| UniProtKB:A0A8M9QA92 | InterPro | 893 | ||||
| UniProtKB:A0A0R4INU5 | InterPro | 538 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnn1a-201
(1)
|
Ensembl | 6,209 nt | ||
| mRNA |
kcnn1a-202
(1)
|
Ensembl | 878 nt | ||
| mRNA |
kcnn1a-203
(1)
|
Ensembl | 1,864 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-39B20 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128248 (1) | 1864 nt | ||
| Genomic | GenBank:BX530024 (1) | 146464 nt | ||
| Polypeptide | UniProtKB:A0A8M9QNQ2 (1) | 896 aa |
- Silic, M.R., Black, M.M., Zhang, G. (2021) Phylogenetic and developmental analyses indicate complex functions of Calcium-Activated Potassium Channels in zebrafish embryonic development. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(10):1477-1493
- Carpaneto Freixas, A.E., Moglie, M.J., Castagnola, T., Salatino, L., Domene, S., Marcovich, I., Gallino, S., Wedemeyer, C., Goutman, J.D., Plazas, P.V., Elgoyhen, A.B. (2020) Unravelling the molecular players at the cholinergic efferent synapse of the zebrafish lateral line. The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(1):47-60
- Tsata, V., Kroehne, V., Reinhardt, S., El-Armouche, A., Brand, M., Wagner, M., Reimer, M.M. (2019) Electrophysiological Properties of Adult Zebrafish Oligodendrocyte Progenitor Cells. Frontiers in Cellular Neuroscience. 13:102
- Skarsfeldt, M.A., Bomholtz, S.H., Lundegaard, P.R., Lopez-Izquierdo, A., Tristani-Firouzi, M., Bentzen, B.H. (2018) Atrium-specific ion channels in the zebrafish-A role of IKACh in atrial repolarization.. Acta physiologica (Oxford, England). 223(3):e13049
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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