ZFIN is now using GRCz12tu for Genomic Data
Gene
serpine1
- ID
- ZDB-GENE-070912-60
- Name
- serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
- Symbol
- serpine1 Nomenclature History
- Previous Names
-
- PAI-1 (1)
- si:ch211-138a11.1
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables serine-type endopeptidase inhibitor activity. Acts upstream of or within negative regulation of plasminogen activation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in bulbus arteriosus and heart. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; artery disease (multiple); liver disease (multiple); lung disease (multiple); and retinal vascular disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Han et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-serpine1 | Lu et al., 2023 | |
| CRISPR2-serpine1 | Lu et al., 2023 | |
| CRISPR3-serpine1 | Lu et al., 2023 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Plasminogen activator inhibitor-1 deficiency | 613329 | ||
| {Transcription of plasminogen activator inhibitor, modulator of} |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Serpin, conserved site | Serpin domain | Serpin family | Serpin superfamily | Serpin superfamily, domain 1 | Serpin superfamily, domain 2 |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QRB8 | InterPro PDB | 392 | ||||||
| UniProtKB:A8WGQ0 | InterPro | 384 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
serpine1-201
(1)
|
Ensembl | 1,789 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-196F2 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174880 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001114559 (1) | 1818 nt | ||
| Genomic | GenBank:BX470232 (1) | 194721 nt | ||
| Polypeptide | UniProtKB:F1QRB8 (1) | 392 aa |
- Cosentino, C.C., Stevens, M.J.A., Eshwar, A.K., Muchaamba, F., Guldimann, C., Stephan, R., Lehner, A. (2025) Uncovering the Pathogenic Mechanisms of Cronobacter turicensis: A Dual Transcriptomics Study Using a Zebrafish Larvae Model. Microbial pathogenesis. :107374107374
- Xia, X., Song, W., Zhang, F., Fan, Y., Zhang, B., Chen, X. (2025) ctdsp2 Knockout Induces Zebrafish Craniofacial Dysplasia via p53 Signaling Activation. International Journal of Molecular Sciences. 26:
- Dou, X., Chen, Z., Liu, Y., Li, Y., Ye, J., Lu, L. (2024) Zebrafish mutants in egln1 display a hypoxic response and develop polycythemia. Life sciences. 344:122564
- Kong, S., Xiao, Y., Chen, L., Jin, Y., Qiao, R., Xu, K., Xu, L., Wang, H. (2024) Apigenin attenuates cisplatin-induced hair cell damage in the zebrafish lateral line. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 194:115099
- Lu, X., Zhang, L., Lin, G.M., Lu, J.G., Cui, Z.B. (2024) Analysis of Differential Gene Expression under Acute Lead or Mercury Exposure in Larval Zebrafish Using RNA-Seq. Animals : an open access journal from MDPI. 14(19):
- Song, W., Xia, X., Fan, Y., Zhang, B., Chen, X. (2024) Functional and Genetic Analyses Unveil the Implication of CDC27 in Hemifacial Microsomia. International Journal of Molecular Sciences. 25(9):
- Liao, Q., Zhu, C., Sun, X., Wang, Z., Chen, X., Deng, H., Tang, J., Jia, S., Liu, W., Xiao, W., Liu, X. (2023) Disruption of sirtuin 7 in zebrafish facilitates hypoxia tolerance. The Journal of biological chemistry. 299(8):105074
- Liu, W., Lin, S., Li, L., Tai, Z., Liu, J.X. (2023) Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance. Cell regeneration (London, England). 12:1010
- Lu, F., Leach, L.L., Gross, J.M. (2023) A CRISPR-Cas9-mediated F0 screen to identify pro-regenerative genes in the zebrafish retinal pigment epithelium. Scientific Reports. 13:31423142
- Wang, N., Lan, C., Lu, H., Li, L., Liao, D., Xu, K., Sun, H., Tang, Y., Wang, Y., Mei, J., Wei, M., Wu, T., Zhu, H. (2023) Preventive effect and mechanism of Tibetan tea extract on thrombosis in arachidonic acid-induced zebrafish determined via RNA-seq transcriptome profiles. PLoS One. 18:e0285216e0285216
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