ZFIN is now using GRCz12tu for Genomic Data
Gene
serpine1
- ID
- ZDB-GENE-070912-60
- Name
- serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
- Symbol
- serpine1 Nomenclature History
- Previous Names
-
- PAI-1 (1)
- si:ch211-138a11.1
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of plasminogen activation; negative regulation of wound healing; and positive regulation of coagulation. Predicted to be active in extracellular region. Is expressed in bulbus arteriosus and heart. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); lung disease (multiple); and peripheral vascular disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Han et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Plasminogen activator inhibitor-1 deficiency | 613329 | ||
| {Transcription of plasminogen activator inhibitor, modulator of} |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023795 | Serpin, conserved site |
| Domain | IPR023796 | Serpin domain |
| Family | IPR000215 | Serpin family |
| Homologous_superfamily | IPR036186 | Serpin superfamily |
| Homologous_superfamily | IPR042178 | Serpin superfamily, domain 1 |
| Homologous_superfamily | IPR042185 | Serpin superfamily, domain 2 |
Domain Details Per Protein
| Protein | Additional Resources | Length | Serpin, conserved site | Serpin domain | Serpin family | Serpin superfamily | Serpin superfamily, domain 1 | Serpin superfamily, domain 2 |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QRB8 | InterPro PDB | 392 | ||||||
| UniProtKB:A8WGQ0 | InterPro | 384 | ||||||
| UniProtKB:A0AC58FX17 | InterPro | 392 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
serpine1-201
(1)
|
Ensembl | 1,789 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers