Gene
samd7
- ID
- ZDB-GENE-070912-549
- Name
- sterile alpha motif domain containing 7
- Symbol
- samd7 Nomenclature History
- Previous Names
-
- si:dkey-52k20.12
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in photoreceptor cell. Human ortholog(s) of this gene implicated in macular degeneration. Orthologous to human SAMD7 (sterile alpha motif domain containing 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Volkov et al., 2024
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Volkov et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| stl888 | Allele with one deletion | Exon 4 | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Macular dystrophy with or without cone dysfunction | 620762 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Polycomb group and chromatin remodeling factors | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:F1R0H6 | InterPro | 526 | |||
| UniProtKB:B3DJI7 | InterPro | 526 | |||
| UniProtKB:A0A8M3B7T1 | InterPro | 527 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-52K20 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195018 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128716 (1) | 1834 nt | ||
| Genomic | GenBank:BX649372 (1) | 249584 nt | ||
| Polypeptide | UniProtKB:A0A8M3B7T1 (1) | 527 aa |
- Volkov, L.I., Ogawa, Y., Somjee, R., Vedder, H.E., Powell, H.E., Poria, D., Meiselman, S., Kefalov, V.J., Corbo, J.C. (2024) Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Proceedings of the National Academy of Sciences of the United States of America. 121:e2402121121e2402121121
- Hurem, S., Martín, L.M., Lindeman, L., Brede, D.A., Salbu, B., Lyche, J.L., Aleström, P., Kamstra, J.H. (2017) Parental exposure to gamma radiation causes progressively altered transcriptomes linked to adverse effects in zebrafish offspring. Environmental pollution (Barking, Essex : 1987). 234:855-863
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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