Gene
myo7bb
- ID
- ZDB-GENE-070912-482
- Name
- myosin VIIBb
- Symbol
- myo7bb Nomenclature History
- Previous Names
-
- si:dkey-261l2.7
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity and cytoskeletal motor activity. Predicted to be involved in system development. Predicted to be located in cytoplasm. Orthologous to human MYO7B (myosin VIIB).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Yang et al., 2023
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la023517Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa17781 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19737 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32906 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32907 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Band 4.1 domain | Class VII myosin, motor domain | FERM/acyl-CoA-binding protein superfamily | FERM central domain | FERM domain | FERM superfamily, second domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin head, motor domain-like | Myosin VII, FERM domain C-lobe, repeat 1 | MyTH4 domain | MyTH4 domain superfamily | PH-like domain superfamily | P-loop containing nucleoside triphosphate hydrolase | SH3 domain | Ubiquitin-like domain superfamily | Unconventional Myosin ATPase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PKU5 | InterPro | 2160 | |||||||||||||||||
| UniProtKB:A0A8M9PNU1 | InterPro | 2189 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
myo7bb-201
(1)
|
Ensembl | 6,591 nt | ||
| mRNA |
myo7bb-202
(1)
|
Ensembl | 6,957 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-5I22 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-261L2 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021467200 (1) | |||
| Genomic | GenBank:BX649390 (1) | 184594 nt | ||
| Polypeptide | UniProtKB:A0A8M9PNU1 (1) | 2189 aa |
- Yang, S., Xie, B.L., Dong, X.P., Wang, L.X., Zhu, G.H., Wang, T., Wu, W.J., Lai, R.S., Tao, R., Guan, M.X., Chen, F.Y., Tan, D.H., Deng, Z., Xie, H.P., Zeng, Y., Xiao, Z.A., Xie, D.H. (2023) cdh23 affects congenital hearing loss through regulating purine metabolism. Frontiers in molecular neuroscience. 16:10795291079529
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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