Gene

nlrc7

ID
ZDB-GENE-070912-478
Name
NLR family CARD domain containing 7
Symbol
nlrc7 Nomenclature History
Previous Names
  • NACHT, LRR and PYD domains-containing protein 12b (1)
  • nlrp12b (1)
  • si:dkey-253d23.12
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome (multiple); and urticaria. Orthologous to several human genes including NLRP12 (NLR family pyrin domain containing 12); NLRP13 (NLR family pyrin domain containing 13); and NLRP14 (NLR family pyrin domain containing 14).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa29724Allele with one point mutationUnknownMissense, Premature StopENU
sa37433Allele with one point mutationUnknownPremature StopENU
sa45754Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With nlrc7 Human Ortholog
No data available
Associated With nlrc7 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR007111 NACHT nucleoside triphosphatase
Domain IPR029495 NACHT-associated domain
Domain IPR041075 NOD1/2, winged helix domain
Domain IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2
Family IPR051261 NOD-like receptor
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Domain Details Per Protein
Protein Additional Resources Length Leucine-rich repeat Leucine-rich repeat domain superfamily NACHT-associated domain NACHT, LRR and PYD domains-containing protein, helical domain HD2 NACHT nucleoside triphosphatase NOD1/2, winged helix domain NOD-like receptor P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M9PEG1 InterPro 1063
UniProtKB:A0A8M9PVV5 InterPro 1380
UniProtKB:A0A8M9P4P1 InterPro 1264
UniProtKB:A0A8M9PSD3 InterPro 1370
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 22
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA nlrc7-201 (1) Ensembl 2,642 nt
mRNA nlrc7-202 (1) Ensembl 4,492 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-253D23ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
No data available
Citations