Gene

map3k20a

ID

ZDB-GENE-070912-386

Name

mitogen-activated protein kinase kinase kinase 20a

Symbol

map3k20a Nomenclature History

Previous Names

zak
si:dkey-15i8.3

Type

protein_coding_gene

Location

Ambiguous Mapping Details/Browsers

Description

Predicted to have MAP kinase kinase kinase activity. Predicted to be involved in activation of MAPKK activity and protein phosphorylation. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in centronuclear myopathy 6 with fiber-type disproportion. Orthologous to human MAP3K20 (mitogen-activated protein kinase kinase kinase 20).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With map3k20a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
centronuclear myopathy 6 with fiber-type disproportion	Alliance	Centronuclear myopathy 6 with fiber-type disproportion	617760
		Split-foot malformation with mesoaxial polydactyly	616890

Associated With map3k20a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily