Gene
map3k20a
- ID
- ZDB-GENE-070912-386
- Name
- mitogen-activated protein kinase kinase kinase 20a
- Symbol
- map3k20a Nomenclature History
- Previous Names
-
- zak
- si:dkey-15i8.3
- Type
- protein_coding_gene
- Location
- Ambiguous Mapping Details/Browsers
- Description
- Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in stress-activated MAPK cascade. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in centronuclear myopathy 6 with fiber-type disproportion. Orthologous to human MAP3K20 (mitogen-activated protein kinase kinase kinase 20).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Snieckute et al., 2023
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Snieckute et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| centronuclear myopathy 6 with fiber-type disproportion | Alliance | Centronuclear myopathy 6 with fiber-type disproportion | 617760 |
| Split-foot malformation with mesoaxial polydactyly | 616890 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001660 | Sterile alpha motif domain |
| Family | IPR051681 | Serine/Threonine Kinases and Pseudokinases |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Protein kinase domain | Protein kinase-like domain superfamily | Serine/Threonine Kinases and Pseudokinases | Serine/threonine-protein kinase, active site | Serine-threonine/tyrosine-protein kinase, catalytic domain | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B0S4Y7 | InterPro | 789 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance