Gene
slitrk3b
- ID
- ZDB-GENE-070912-352
- Name
- SLIT and NTRK-like family, member 3b
- Symbol
- slitrk3b Nomenclature History
- Previous Names
-
- si:dkey-116g14.1
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to be involved in axonogenesis and positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be active in GABA-ergic synapse and postsynaptic density membrane. Is expressed in head; nervous system; and neuroepithelial cell. Orthologous to human SLITRK3 (SLIT and NTRK like family member 3).
- Genome Resources
- Note
-
Should be associated with Gene ID: 137488017 as NCBI Gene ID: 100007758 was merged into Gene ID: 137488017.
- Comparative Information
-
- All Expression Data
- 7 figures from Round et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-slitrk3b | (2) | |
CRISPR2-slitrk3b | (2) | |
CRISPR3-slitrk3b | (2) | |
CRISPR4-slitrk3b | (2) | |
CRISPR5-slitrk3b | (2) | |
CRISPR6-slitrk3b | (2) | |
CRISPR7-slitrk3b | (2) | |
CRISPR8-slitrk3b | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Cysteine-rich flanking region, C-terminal | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype |
---|---|---|---|---|---|---|
UniProtKB:B0S7B6 | InterPro | 882 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
slitrk3b-201
(1)
|
Ensembl | 2,649 nt | ||
mRNA |
slitrk3b-202
(1)
|
Ensembl | 3,043 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-116G14 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_001346099 (1) | |||
Genomic | GenBank:BX663495 (1) | 80339 nt | ||
Polypeptide | UniProtKB:B0S7B6 (1) | 882 aa |
- Moreno-Mateos, M.A., Vejnar, C.E., Beaudoin, J.D., Fernandez, J.P., Mis, E.K., Khokha, M.K., Giraldez, A.J. (2015) CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo. Nature Methods. 12:982-8
- Panza, P., Sitko, A.A., Maischein, H.M., Koch, I., Flötenmeyer, M., Wright, G.J., Mandai, K., Mason, C.A., Söllner, C. (2015) The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm. Neural Development. 10:23
- Round, J., Ross, B., Angel, M., Shields, K., and Lom, B. (2014) Slitrk gene duplication and expression in the developing zebrafish nervous system. Developmental Dynamics : an official publication of the American Association of Anatomists. 243(2):339-49
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