Gene
myo10
- ID
- ZDB-GENE-070912-277
- Name
- myosin X
- Symbol
- myo10 Nomenclature History
- Previous Names
-
- myo10b (1)
- myo10l2
- si:ch211-283p23.2
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and plus-end directed microfilament motor activity. Predicted to be involved in cytoskeleton-dependent intracellular transport; regulation of cell shape; and regulation of filopodium assembly. Predicted to be located in cytoplasm. Predicted to be active in filopodium. Is expressed in midbrain hindbrain boundary; otic vesicle; and rhombomere. Orthologous to human MYO10 (myosin X).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Sittaramane et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la014975Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa11921 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19843 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19844 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19845 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa38351 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39909 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Actin-based Motor Myosin | Band 4.1 domain | Class X myosin, motor domain | FERM/acyl-CoA-binding protein superfamily | FERM central domain | FERM domain | FERM superfamily, second domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin head, motor domain-like | Myosin X, FERM domain C-lobe | Myosin X, N-terminal SH3 domain | MyTH4 domain | MyTH4 domain superfamily | PH-like domain superfamily | Pleckstrin homology domain | P-loop containing nucleoside triphosphate hydrolase | Ras-associating domain | Unconventional myosin-X, coiled coil domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9P844 | InterPro | 1425 | |||||||||||||||||||
| UniProtKB:A0A8M6Z236 | InterPro | 1425 | |||||||||||||||||||
| UniProtKB:A0A8M9PXE2 | InterPro | 2069 | |||||||||||||||||||
| UniProtKB:B0S541 | InterPro | 2069 | |||||||||||||||||||
| UniProtKB:A0A8M3B0G0 | InterPro | 2013 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-220F13 | ZFIN Curated Data | |
| Contained in | BAC | CH211-283P23 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005171401 (1) | |||
| Genomic | GenBank:BX005083 (1) | 212081 nt | ||
| Polypeptide | UniProtKB:A0A8M9PXE2 (1) | 2069 aa |
- Nikolaou, N., Gordon, P.M., Hamid, F., Taylor, R., Lloyd-Jones, J., Makeyev, E.V., Houart, C. (2022) Cytoplasmic pool of U1 spliceosome protein SNRNP70 shapes the axonal transcriptome and regulates motor connectivity. Current biology : CB. 32(23):5099-5115.e8
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Sittaramane, V., and Chandrasekhar, A. (2008) Expression of unconventional myosin genes during neuronal development in zebrafish. Gene expression patterns : GEP. 8(3):161-170
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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