Gene
si:ch211-195h23.3
- ID
- ZDB-GENE-070912-174
- Name
- si:ch211-195h23.3
- Symbol
- si:ch211-195h23.3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within negative regulation of NF-kappaB transcription factor activity. Located in nucleus. Is expressed in kidney and spleen. Orthologous to several human genes including GBP1 (guanylate binding protein 1); GBP2 (guanylate binding protein 2); and GBP3 (guanylate binding protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Chang et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa19856 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19857 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31297 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa38353 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CARD8/ASC/NALP1, CARD domain | CARD domain | Death-like domain superfamily | FIIND domain | NLRP Inflammasome |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QAJ2 | InterPro | 658 | |||||
| UniProtKB:A0A8M9QJG0 | InterPro | 469 | |||||
| UniProtKB:A0A8M9QF56 | InterPro | 917 | |||||
| UniProtKB:A0A8M9QAI5 | InterPro | 998 | |||||
| UniProtKB:A0A8M9PRT1 | InterPro | 730 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:ch211-195h23.3-201
(1)
|
Ensembl | 1,830 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-195H23 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001130402 (1) | 2459 nt | ||
| Genomic | GenBank:CR847981 (1) | 197506 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q4E9 (1) | 1001 aa |
No data available
- Hu, Y.W., Wu, X.M., Ren, S.S., Cao, L., Nie, P., Chang, M.X. (2017) NOD1 deficiency impairs CD44a/Lck as well as PI3K/Akt pathway. Scientific Reports. 7:2979
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Jin, T., Huang, M., Smith, P., Jiang, J., and Xiao, T.S. (2013) Structure of the caspase-recruitment domain from a zebrafish guanylate-binding protein. Acta crystallographica. Section F, Structural biology and crystallization communications. 69(8):855-860
- Chang, M.X., Chen, W.Q., and Nie, P. (2010) Structure and expression pattern of teleost caspase recruitment domain (CARD) containing proteins that are potentially involved in NF-kappaB signalling. Developmental and comparative immunology. 34(1):1-13
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