Gene
c8b
- ID
- ZDB-GENE-070912-163
- Name
- complement component 8, beta polypeptide
- Symbol
- c8b Nomenclature History
- Previous Names
-
- si:ch211-188c16.3
- wu:fi18d09
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to be involved in complement activation. Predicted to act upstream of or within complement activation, alternative pathway; complement activation, classical pathway; and killing of cells of another organism. Predicted to be located in extracellular region. Predicted to be part of membrane attack complex. Predicted to be active in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in type II complement component 8 deficiency. Orthologous to human C8B (complement C8 beta chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Takada et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type II complement component 8 deficiency | Alliance | C8 deficiency, type II | 613789 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020863 | Membrane attack complex component/perforin domain, conserved site |
| Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| Domain | IPR020864 | Membrane attack complex component/perforin (MACPF) domain |
| Domain | IPR048831 | Complement components C8A/B/C6, EGF-like domain |
| Family | IPR001862 | Membrane attack complex component/perforin/complement C9 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Complement components C8A/B/C6, EGF-like domain | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | Membrane attack complex component/perforin/complement C9 | Membrane attack complex component/perforin domain, conserved site | Membrane attack complex component/perforin (MACPF) domain | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A8HAJ8 | InterPro | 562 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-188C16 | ZFIN Curated Data | |
| Encodes | EST | fi18d09 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001256723 (1) | 2270 nt | ||
| Genomic | GenBank:CR848026 (1) | 118727 nt | ||
| Polypeptide | UniProtKB:A8HAJ8 (1) | 562 aa |
- Fu, X., Chen, Y., Wang, L., Zhou, Q., Li, M., Song, Y., Li, Y., Zhao, F., Chen, S. (2021) Identification and functional analysis of the perforin-1 like gene in disease resistance in half smooth tongue sole (Cynoglossus semilaevis). Developmental and comparative immunology. 122:104135
- Li, L., Yang, W., Shen, Y., Xu, X., Li, J. (2020) Fish complement C8 evolution, functional network analyses, and the theoretical interaction between C8 alpha chain and CD59. Molecular immunology. 128:235-248
- Wu, X.M., Cao, L., Hu, Y.W., Chang, M.X. (2019) Transcriptomic characterization of adult zebrafish infected with Streptococcus agalactiae. Fish & shellfish immunology. 94:355-372
- Takada, N., Omae, M., Sagawa, F., Chi, N.C., Endo, S., Kozawa, S., Sato, T.N. (2017) Re-evaluating functional landscape of the cardiovascular system during development. Biology Open. 6(11):1756-1770
- Zheng, H., Ji, W., Zhang, G.R., Zhang, X.T., Shi, Z.C., Wei, K.J., Yang, R.B., Gardner, J.P. (2016) Molecular Characterization and Expression Analyses of the Complement Component C8α, C8β and C9 Genes in Yellow Catfish (Pelteobagrus fulvidraco) after the Aeromonas hydrophila Challenge. International Journal of Molecular Sciences. 17(3):345
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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