Gene

kif5aa

ID

ZDB-GENE-070912-141

Name

kinesin family member 5A, a

Symbol

kif5aa Nomenclature History

Previous Names

kif5a
vrt (1)
si:ch211-166e11.4 (1)
vertigo (1)
wu:fj61a10 (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have ATP-dependent microtubule motor activity, plus-end-directed and microtubule binding activity. Involved in axonal transport of mitochondrion and neuron projection maintenance. Predicted to localize to kinesin complex and microtubule. Is expressed in gonad; nervous system; neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; hereditary spastic paraplegia 10; multiple sclerosis; prostate cancer; and rheumatoid arthritis. Orthologous to human KIF5A (kinesin family member 5A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7151650 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kif5aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Myoclonus, intractable, neonatal	617235
		Spastic paraplegia 10, autosomal dominant	604187
		{Amyotrophic lateral sclerosis, susceptibility to, 25}	617921

Associated With kif5aa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019821	Kinesin motor domain, conserved site
Domain	IPR001752	Kinesin motor domain
Family	IPR027640	Kinesin-like protein
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily