Gene
paplna
- ID
- ZDB-GENE-070815-4
- Name
- papilin a, proteoglycan-like sulfated glycoprotein
- Symbol
- paplna Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within extracellular matrix organization. Predicted to be located in extracellular region. Orthologous to human PAPLN (papilin, proteoglycan like sulfated glycoprotein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020901 | Proteinase inhibitor I2, Kunitz, conserved site |
| Domain | IPR002223 | Pancreatic trypsin inhibitor Kunitz domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ADAMTS/ADAMTS-like | ADAMTS/ADAMTS-like, cysteine-rich domain 3 | ADAMTS/ADAMTS-like, Spacer 1 | ADAMTS and ADAMTS-like | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Immunoglobulin V-set domain | Pancreatic trypsin inhibitor Kunitz domain | Pancreatic trypsin inhibitor Kunitz domain superfamily | PLAC | Proteinase inhibitor I2, Kunitz, conserved site | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1QL06 | InterPro | 1163 | |||||||||||||||||
| UniProtKB:A0A8M9P9Q0 | InterPro | 719 | |||||||||||||||||
| UniProtKB:A0A8M9PLN8 | InterPro | 881 | |||||||||||||||||
| UniProtKB:A0A8M9P0S4 | InterPro | 1187 | |||||||||||||||||
| UniProtKB:A0A8M9P0S8 | InterPro | 826 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
paplna-201
(1)
|
Ensembl | 2,601 nt | ||
| mRNA |
paplna-202
(1)
|
Ensembl | 219 nt | ||
| mRNA |
paplna-203
(1)
|
Ensembl | 3,079 nt | ||
| mRNA |
paplna-204
(1)
|
Ensembl | 2,689 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-392O1 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-469D17 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021467497 (1) | 4056 nt | ||
| Genomic | GenBank:CABZ01067323 (1) | 47553 nt | ||
| Polypeptide | UniProtKB:A0A8M9P0S4 (1) | 1187 aa |
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huxley-Jones, J., Clarke, T.K., Beck, C., Toubaris, G., Robertson, D.L., and Boot-Handford, R.P. (2007) The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio. BMC Evolutionary Biology. 7(1):63
- Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466
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