Gene
adam8b
- ID
- ZDB-GENE-070808-1
- Name
- ADAM metallopeptidase domain 8b
- Symbol
- adam8b Nomenclature History
- Previous Names
-
- CD156b
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable cell adhesion molecule binding activity and metalloendopeptidase activity. Predicted to be involved in several processes, including positive regulation of cellular extravasation; positive regulation of membrane protein ectodomain proteolysis; and proteolysis. Predicted to be located in membrane. Is expressed in ovarian follicle. Orthologous to human ADAM8 (ADAM metallopeptidase domain 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6236 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10008 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22036 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41968 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 4 of 4
Show
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ADAM, cysteine-rich domain | Disintegrin, conserved site | Disintegrin domain | Disintegrin domain superfamily | EGF-like domain | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin | Peptidase M12B, propeptide | Reprolysin domain, adamalysin-type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AY73 | InterPro | 794 | |||||||||
| UniProtKB:E7F6J8 | InterPro | 819 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adam8b-201
(1)
|
Ensembl | 3,402 nt | ||
| mRNA |
adam8b-202
(1)
|
Ensembl | 741 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-14G24 |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_003199573 (1) | 2720 nt | ||
| Genomic | GenBank:CR854953 (2) | 85566 nt | ||
| Polypeptide | UniProtKB:E7F6J8 (1) | 819 aa |
- Hu, T., Liu, L., Wang, H., Yang, M., Xu, B., Xie, H., Lin, Z., Jin, X., Wang, P., Liu, Y., Sun, H., Liu, S. (2024) RCAN family member 3 deficiency contributes to noncompaction of the ventricular myocardium. Journal of genetics and genomics = Yi chuan xue bao. 51(5):543-553
- Wu, X.J., Liu, D.T., Chen, S., Hong, W., Zhu, Y. (2020) Impaired oocyte maturation and ovulation in membrane progestin receptor (mPR) knockouts in zebrafish. Molecular and Cellular Endocrinology. 511:110856
- Wu, X.J., Zhu, Y. (2019) Downregulation of nuclear progestin receptor (Pgr) and subfertility in double knockouts of progestin receptor membrane component 1 (pgrmc1) and pgrmc2 in zebrafish. General and comparative endocrinology. 285:113275
- Liu, D.T., Carter, N.J., Wu, X.J., Hong, W.S., Chen, S.X., Zhu, Y. (2018) Progestin and Nuclear Progestin Receptor Are Essential for Upregulation of Metalloproteinase in Zebrafish Preovulatory Follicles. Frontiers in endocrinology. 9:517
- Wu, X.J., Thomas, P., Zhu, Y. (2018) Pgrmc1 Knockout Impairs Oocyte Maturation in Zebrafish. Frontiers in endocrinology. 9:560
- Liu, D., Brewer, M.S., Chen, S., Hong, W., Zhu, Y. (2017) Transcriptomic Signatures for Ovulation in Vertebrates. General and comparative endocrinology. 247:74-86
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Tokumasu, Y., Iida, A., Wang, Z., Ansai, S., Kinoshita, M., Sehara-Fujisawa, A. (2016) ADAM12-deficient zebrafish exhibit retardation in body growth at the juvenile stage without developmental defects. Development, growth & differentiation. 58(4):409-421
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wang, Y., Yang, L., Zhou, K., Zhang, Y., Song, Z., He, S. (2015) Evidence for adaptation to the Tibetan Plateau inferred from Tibetan loach transcriptomes. Genome biology and evolution. 7(11):2970-82
1 - 10 of 12
Show