Gene
jak3
- ID
- ZDB-GENE-070725-4
- Name
- Janus kinase 3 (a protein tyrosine kinase, leukocyte)
- Symbol
- jak3 Nomenclature History
- Previous Names
-
- sb:eu418
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in T cell differentiation in thymus and natural killer cell differentiation. Predicted to localize to cytoskeleton and membrane. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; adult T-cell leukemia; juvenile myelomonocytic leukemia; and megakaryocytic leukemia. Is expressed in thymus. Orthologous to human JAK3 (Janus kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu418 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| janus kinase-3 deficiency | Alliance | SCID, autosomal recessive, T-negative/B-positive type | 600802 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| severe combined immunodeficiency | jak3mdu9/mdu9 | standard conditions | Basheer et al., 2022 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000299 | FERM domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR019748 | FERM central domain |
| Domain | IPR019749 | Band 4.1 domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR041046 | JAK, FERM F2 lobe domain |
| Domain | IPR041155 | FERM F1 lobe ubiquitin-like domain |
| Domain | IPR041381 | JAK1-3/TYK2, pleckstrin homology-like domain |
| Family | IPR016251 | Tyrosine-protein kinase, non-receptor Jak/Tyk2 |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | Band 4.1 domain | FERM central domain | FERM domain | FERM F1 lobe ubiquitin-like domain | JAK1-3/TYK2, pleckstrin homology-like domain | JAK, FERM F2 lobe domain | PH-like domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, non-receptor Jak/Tyk2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B0V237
|
1103 |
Interactions and Pathways
No data available
Plasmids
No data available