Gene
daam2
- ID
- ZDB-GENE-070709-1
- Name
- dishevelled associated activator of morphogenesis 2
- Symbol
- daam2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable actin binding activity and small GTPase binding activity. Predicted to be involved in negative regulation of oligodendrocyte differentiation; positive regulation of canonical Wnt signaling pathway; and regulation of non-canonical Wnt signaling pathway. Predicted to act upstream of or within actin cytoskeleton organization. Human ortholog(s) of this gene implicated in familial nephrotic syndrome. Orthologous to human DAAM2 (dishevelled associated activator of morphogenesis 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027877Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa11626 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23181 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23182 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa23183 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa36524 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-daam2 | Debaenst et al., 2025 | |
| MO1-daam2 | N/A | Kida et al., 2007 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Nephrotic syndrome, type 24 | 619263 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | Formin, FH2 domain | Formin, FH2 domain superfamily | Formin, FH3 domain | Formin, GTPase-binding domain | Formin Homology | Rho GTPase-binding/formin homology 3 (GBD/FH3) domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1PZ97 | InterPro | 1095 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-309K8 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001338872 (1) | 5903 nt | ||
| Genomic | GenBank:CU856355 (2) | 80557 nt | ||
| Polypeptide | UniProtKB:A0A8M1PZ97 (1) | 1095 aa |
- Debaenst, S., Jarayseh, T., De Saffel, H., Bek, J.W., Boone, M., Josipovic, I., Kibleur, P., Kwon, R.Y., Coucke, P.J., Willaert, A. (2025) Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility. eLIFE. 13:
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Kida, Y.S., Sato, T., Miyasaka, K.Y., Suto, A., and Ogura, T. (2007) Daam1 regulates the endocytosis of EphB during the convergent extension of the zebrafish notochord. Proceedings of the National Academy of Sciences of the United States of America. 104(16):6708-6713
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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