Gene
myo3b
- ID
- ZDB-GENE-070706-2
- Name
- myosin IIIB
- Symbol
- myo3b Nomenclature History
- Previous Names
-
- si:dkey-249g23.1
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable microfilament motor activity and protein serine/threonine kinase activity. Predicted to be involved in positive regulation of filopodium assembly; regulation of actin filament length; and sensory perception of sound. Predicted to act upstream of or within protein phosphorylation and visual perception. Predicted to be located in cytoplasm; cytoskeleton; and stereocilium. Predicted to be part of myosin complex. Predicted to be active in filopodium tip; photoreceptor inner segment; and stereocilium tip. Orthologous to human MYO3B (myosin IIIB).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Desban et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa7171 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa15983 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa27329 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa34546 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa41340 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-myo3b | Charlton-Perkins et al., 2019 | |
CRISPR2-myo3b | Charlton-Perkins et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
Binding_site | IPR000048 | IQ motif, EF-hand binding site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR001609 | Myosin head, motor domain-like |
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Domain Details Per Protein
Protein | Additional Resources | Length | Class III myosin, motor domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin head, motor domain-like | Myosin-III family with kinase activity | P-loop containing nucleoside triphosphate hydrolase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9QFR3 | InterPro | 1305 | ||||||||||
UniProtKB:A0A8M1QKE9 | InterPro | 1307 | ||||||||||
UniProtKB:A0A8M9PSI3 | InterPro | 1022 | ||||||||||
UniProtKB:A0AB32TYB4 | InterPro | 1285 | ||||||||||
UniProtKB:A0AB32U0A6 | InterPro | 264 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-235G13 | ZFIN Curated Data | |
Contained in | BAC | DKEY-249G23 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_001920252 (1) | 4213 nt | ||
Genomic | GenBank:CR394567 (1) | 189488 nt | ||
Polypeptide | UniProtKB:A0A8M1QKE9 (1) | 1307 aa |
- Prendergast, A.E., Jim, K.K., Marnas, H., Desban, L., Quan, F.B., Djenoune, L., Laghi, V., Hocquemiller, A., Lunsford, E.T., Roussel, J., Keiser, L., Lejeune, F.X., Dhanasekar, M., Bardet, P.L., Levraud, J.P., van de Beek, D., Vandenbroucke-Grauls, C.M.J.E., Wyart, C. (2023) CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Current biology : CB. 33(5):940-956.e10
- Charlton-Perkins, M., Almeida, A.D., MacDonald, R.B., Harris, W.A. (2019) Genetic control of cellular morphogenesis in Müller glia. Glia. 67(7):1401-1411
- Desban, L., Prendergast, A., Roussel, J., Rosello, M., Geny, D., Wyart, C., Bardet, P.L. (2019) Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons. PLoS Biology. 17:e3000235
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Steinke, D., Salzburger, W., Braasch, I., and Meyer, A. (2006) Many genes in fish have species-specific asymmetric rates of molecular evolution. BMC Genomics. 7(1):20
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