Gene

hscb

ID
ZDB-GENE-070705-97
Name
HscB mitochondrial iron-sulfur cluster cochaperone
Symbol
hscb Nomenclature History
Previous Names
  • si:ch211-207k7.4
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable ATPase activator activity and protein-folding chaperone binding activity. Predicted to be involved in [2Fe-2S] cluster assembly. Predicted to act upstream of or within protein complex oligomerization. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in blood island. Used to study sideroblastic anemia. Human ortholog(s) of this gene implicated in sideroblastic anemia 5. Orthologous to human HSCB (HscB mitochondrial iron-sulfur cluster cochaperone).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Crispin et al., 2020
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Crispin et al., 2020
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa44600Allele with one point mutationUnknownUnknownENU
1 - 1 of 1
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-hscbN/ACrispin et al., 2020
MO2-hscbN/ACrispin et al., 2020
1 - 2 of 2
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Human Disease
Associated With hscb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
sideroblastic anemia 5 Alliance ?Anemia, sideroblastic, 5 619523
1 - 1 of 1
Associated With hscb Via Experimental Models
1 - 1 of 1
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001623 DnaJ domain
Domain IPR009073 Co-chaperone HscB, C-terminal oligomerisation domain
Family IPR004640 Co-chaperone Hsc20
Homologous_superfamily IPR036386 HscB, C-terminal domain superfamily
Homologous_superfamily IPR036869 Chaperone J-domain superfamily
1 - 5 of 5
Domain Details Per Protein
Protein Additional Resources Length Chaperone J-domain superfamily Co-chaperone Hsc20 Co-chaperone HscB, C-terminal oligomerisation domain DnaJ domain HscB, C-terminal domain superfamily
UniProtKB:B0V1J6 InterPro 267
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 5
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA si:ch211-207k7.4-201 (1) Ensembl 963 nt
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-207K7ZFIN Curated Data
1 - 1 of 1
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanHSCB22
Phylogenetic tree (1)
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseHscb5
Phylogenetic tree (1)
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations