Gene

hscb

ID

ZDB-GENE-070705-97

Name

HscB mitochondrial iron-sulfur cluster cochaperone

Symbol

hscb Nomenclature History

Previous Names

si:ch211-207k7.4

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have ATPase activator activity and chaperone binding activity. Predicted to be involved in [2Fe-2S] cluster assembly. Predicted to localize to mitochondrion. Orthologous to human HSCB (HscB mitochondrial iron-sulfur cluster cochaperone).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Crispin et al., 2020

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Crispin et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hscb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Anemia, sideroblastic, 5	619523

Associated With hscb Via Experimental Models

Human Disease	Fish	Conditions	Citations
sideroblastic anemia	WT + MO1-hscb	standard conditions	Crispin et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001623	DnaJ domain
Domain	IPR009073	Co-chaperone HscB, C-terminal oligomerisation domain
Family	IPR004640	Co-chaperone Hsc20
Homologous_superfamily	IPR036386	HscB, C-terminal domain superfamily
Homologous_superfamily	IPR036869	Chaperone J-domain superfamily