Gene
myhz1.3
- ID
- ZDB-GENE-070705-74
- Name
- myosin, heavy polypeptide 1.3, skeletal muscle
- Symbol
- myhz1.3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in system development. Predicted to be located in myofibril. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in adaxial cell; fast muscle cell; and trunk. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; disease of cellular proliferation; and distal arthrogryposis type 7. Orthologous to several human genes including MYH1 (myosin heavy chain 1); MYH4 (myosin heavy chain 4); and MYH8 (myosin heavy chain 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6057 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10927 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20463 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40477 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-myha,myhc4,myhz1.1,myhz1.2,myhz1.3,myhz2 | Lin et al., 2025 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001609 | Myosin head, motor domain-like |
| Domain | IPR002928 | Myosin tail |
| Domain | IPR004009 | Myosin, N-terminal, SH3-like |
| Homologous_superfamily | IPR008989 | Myosin S1 fragment, N-terminal |
| Homologous_superfamily | IPR014751 | DNA repair protein XRCC4-like, C-terminal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | DNA repair protein XRCC4-like, C-terminal | Kinesin motor domain superfamily | Myosin head, motor domain-like | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin tail | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B8A569 | InterPro | 1937 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
myhz1.3-201
(1)
|
Ensembl | 5,961 nt | ||
| mRNA |
myhz1.3-202
(1)
|
Ensembl | 5,814 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-158M24 | ZFIN Curated Data | |
| Encodes | EST | zf-e68 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001923979 (1) | 5960 nt | ||
| Genomic | GenBank:BX510649 (1) | 189844 nt | ||
| Polypeptide | UniProtKB:B8A569 (1) | 1937 aa |
No data available
- Lin, S.J., Huang, K., Petree, C., Qin, W., Varshney, P., Varshney, G.K. (2025) Optimizing gRNA selection for high-penetrance F0 CRISPR screening for interrogating disease gene function. Nucleic acids research. 53:
- Liu, G., Ito, T., Kijima, Y., Yoshitake, K., Asakawa, S., Watabe, S., Kinoshita, S. (2022) Zebrafish Danio rerio myotomal muscle structure and growth from a spatial transcriptomics perspective. Genomics. 114(5):110477
- Garcia de la Serrana, D., Wreggelsworth, K., Johnston, I.A. (2018) Duplication of a Single myhz1.1 Gene Facilitated the Ability of Goldfish (Carassius auratus) to Alter Fast Muscle Contractile Properties With Seasonal Temperature Change. Frontiers in Physiology. 9:1724
- Kwon, O.K., Kim, S.J., Lee, S. (2018) First profiling of lysine crotonylation of myofilament proteins and ribosomal proteins in zebrafish embryos. Scientific Reports. 8:3652
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Asaduzzaman, M., Shakur Ahammad, A.K., Asakawa, S., Kinoshita, S., Watabe, S. (2016) 5′-flanking sequences of zebrafish fast myosin heavy chain genes regulate unique expression in the anterior, medial subsection and posterior tail somites of the skeletal muscle. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 191:1-12
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Nord, H., Burguiere, A.C., Muck, J., Nord, C., Ahlgren, U., and von Hofsten, J. (2014) Differential regulation of myosin heavy chains defines new muscle domains in zebrafish. Molecular biology of the cell. 25(8):1384-95
- Nord, H., Skalman, L.N., and von Hofsten, J. (2013) Six1 regulates proliferation of Pax7-positive muscle progenitors in zebrafish. Journal of Cell Science. 126(Pt 8):1868-80
- Yao, Z., Farr, G.H., Tapscott, S.J., and Maves, L. (2013) Pbx and Prdm1a transcription factors differentially regulate subsets of the fast skeletal muscle program in zebrafish. Biology Open. 2(6):546-555
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