Gene
dio3b
- ID
- ZDB-GENE-070705-53
- Name
- iodothyronine deiodinase 3b
- Symbol
- dio3b Nomenclature History
- Previous Names
-
- D3 (1)
- dio3
- si:ch211-156m19.1
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables thyroxine 5-deiodinase activity. Acts upstream of or within several processes, including pharyngeal system development; regulation of neural retina development; and swimming behavior. Predicted to be located in membrane. Is expressed in several structures, including brain; eye; liver; pleuroperitoneal region; and yolk. Orthologous to human DIO3 (iodothyronine deiodinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Iodothyronine deiodinase | Iodothyronine deiodinase, active site | Iodothyronine deiodinase I/III |
|---|---|---|---|---|---|
| UniProtKB:A0A3G0ZGD9 | InterPro | 269 |
1 - 1 of 1
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
- Lazcano, I., Pech-Pool, S.M., Maldonado-Lira, M.F., Olvera, A., Darras, V.M., Orozco, A. (2024) Ontogeny of Thyroid Hormone Signaling in the Retina of Zebrafish: Effects of Thyroidal Status on Retinal Morphology, Cell Survival, and Color Preference. International Journal of Molecular Sciences. 25(22):
- Volkov, L.I., Ogawa, Y., Somjee, R., Vedder, H.E., Powell, H.E., Poria, D., Meiselman, S., Kefalov, V.J., Corbo, J.C. (2024) Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Proceedings of the National Academy of Sciences of the United States of America. 121:e2402121121e2402121121
- Colella, M., Cuomo, D., Nittoli, V., Amoresano, A., Porciello, A., Reale, C., Roberto, L., Russo, F., Russo, N.A., De Felice, M., Mallardo, M., Ambrosino, C. (2023) A Cross-Species Analysis Reveals Dysthyroidism of the Ovaries as a Common Trait of Premature Ovarian Aging. International Journal of Molecular Sciences. 24(3):
- Schoenmakers, E., Marelli, F., Jørgensen, H.F., Visser, W.E., Moran, C., Groeneweg, S., Avalos, C., Jurgens, S.J., Figg, N., Finigan, A., Wali, N., Agostini, M., Wardle-Jones, H., Lyons, G., Rusk, R., Gopalan, D., Twiss, P., Visser, J.J., Goddard, M., Nashef, S.A.M., Heijmen, R., Clift, P., Sinha, S., Pirruccello, J.P., Ellinor, P.T., Busch-Nentwich, E.M., Ramirez-Solis, R., Murphy, M.P., Persani, L., Bennett, M., Chatterjee, K. (2023) Selenoprotein deficiency disorder predisposes to aortic aneurysm formation. Nature communications. 14:79947994
- Ding, W., Chen, Y., Sultan, Y., Ma, J., Feng, Y., Li, X. (2022) Effect of Acute Exposure to the Ionic Liquid 1-Methyl-3-octylimidazolium Chloride on the Embryonic Development and Larval Thyroid System of Zebrafish. Animals : an open access journal from MDPI. 12(11)
- Walter, K.M., Singh, L., Singh, V., Lein, P.J. (2021) Investigation of NH3 as a selective thyroid hormone receptor modulator in larval zebrafish (Danio rerio). Neurotoxicology. 84:96-104
- Fu, J., Guo, Y., Wang, M., Yang, L., Han, J., Lee, J.S., Zhou, B. (2020) Bioconcentration of 2,4,6-tribromophenol (TBP) and thyroid endocrine disruption in zebrafish larvae. Ecotoxicology and environmental safety. 206:111207
- Lee, S., Eghan, K., Lee, J., Yoo, D., Yoon, S., Kim, W.K. (2020) Zebrafish Embryonic Exposure to BPAP and Its Relatively Weak Thyroid Hormone-Disrupting Effects. Toxics. 8(4):
- Li, J., Dong, T., Keerthisinghe, T.P., Chen, H., Li, M., Chu, W., Yang, J., Hu, Z., Snyder, S.A., Dong, W., Fang, M. (2020) Long-term oxytetracycline exposure potentially alters brain thyroid hormone and serotonin homeostasis in zebrafish. Journal of hazardous materials. 399:123061
- Li, M., Yao, L., Chen, H., Ni, X., Xu, Y., Dong, W., Fang, M., Chen, D., Aowuliji, ., Xu, L., Zhao, B., Deng, J., Kwok, K.W., Yang, J., Dong, W. (2020) Chiral toxicity of muscone to embryonic zebrafish heart. Aquatic toxicology (Amsterdam, Netherlands). 222:105451
1 - 10 of 52
Show