ZFIN is now using GRCz12tu for Genomic Data
Gene

adamts12

ID
ZDB-GENE-070705-471
Name
ADAM metallopeptidase with thrombospondin type 1 motif, 12
Symbol
adamts12 Nomenclature History
Previous Names
  • si:dkey-43l20.2
  • unm_sa1731
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Genome Assembly
GRCz12tu
Annotation Status
Current
Description
Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization and proteolysis. Predicted to be active in extracellular matrix. Is expressed in several structures, including digestive system; eye; heart; pleuroperitoneal region; and thymus. Orthologous to human ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Brunet et al., 2015
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Lin et al., 2023
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa1731Allele with one point mutationUnknownPremature StopENU
sa10586Allele with one point mutationUnknownSplice SiteENU
sa15083Allele with one point mutationUnknownSplice SiteENU
sa20346Allele with one point mutationUnknownPremature StopENU
sa25290Allele with one point mutationUnknownSplice SiteENU
sa31415Allele with one point mutationUnknownSplice SiteENU
sa33532Allele with one point mutationUnknownPremature StopENU
sa40362Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-adamts12N/ALin et al., 2023
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Human Disease
Associated With adamts12 Human Ortholog
No data available
Associated With adamts12 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001590 Peptidase M12B, ADAM/reprolysin
Domain IPR006586 ADAM, cysteine-rich domain
Domain IPR010294 ADAMTS/ADAMTS-like, Spacer 1
Domain IPR010909 PLAC
Domain IPR041645 ADAMTS, cysteine-rich domain 2
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Domain Details Per Protein
Protein Additional Resources Length ADAM, cysteine-rich domain ADAMTS/ADAMTS-like ADAMTS/ADAMTS-like, cysteine-rich domain 3 ADAMTS/ADAMTS-like, Spacer 1 ADAMTS and ADAMTS-like ADAMTS, cysteine-rich domain 2 Metallopeptidase, catalytic domain superfamily Peptidase M12B, ADAM/reprolysin PLAC Thrombospondin type-1 (TSP1) repeat Thrombospondin type-1 (TSP1) repeat superfamily
UniProtKB:A0AB32TPW6 InterPro 1228
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Transcripts
Genome Browsers
Genome Assembly: GRCz11Chromosome: 5
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA adamts12-201 (1) Ensembl 8,713 nt
mRNA adamts12-202 (1) Ensembl 656 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-155M12ZFIN Curated Data
Contained inBACDKEY-43L20
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Sequences
Genome Browsers
Genome Assembly: GRCz12tuChromosome: 5
Orthology
Comparative Orthology
Alliance
Species Symbol Chromosome Accession # Evidence
HumanADAMTS125
Amino acid sequence comparison (2)
MouseAdamts1215
Amino acid sequence comparison (1)
Citations
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