ZFIN is now using GRCz12tu for Genomic Data
Gene
adamts12
- ID
- ZDB-GENE-070705-471
- Name
- ADAM metallopeptidase with thrombospondin type 1 motif, 12
- Symbol
- adamts12 Nomenclature History
- Previous Names
-
- si:dkey-43l20.2
- unm_sa1731
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization and proteolysis. Predicted to be active in extracellular matrix. Is expressed in several structures, including digestive system; eye; heart; pleuroperitoneal region; and thymus. Orthologous to human ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Brunet et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Lin et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa1731 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa10586 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa15083 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa20346 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa25290 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa31415 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa33532 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa40362 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | ADAM, cysteine-rich domain | ADAMTS/ADAMTS-like | ADAMTS/ADAMTS-like, cysteine-rich domain 3 | ADAMTS/ADAMTS-like, Spacer 1 | ADAMTS and ADAMTS-like | ADAMTS, cysteine-rich domain 2 | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin | PLAC | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0AB32TPW6 | InterPro | 1228 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
adamts12-201
(1)
|
Ensembl | 8,713 nt | ||
mRNA |
adamts12-202
(1)
|
Ensembl | 656 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-155M12 | ZFIN Curated Data | |
Contained in | BAC | DKEY-43L20 |
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Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_068221333 (1) | GRCz12tu | 7718 nt | |
Genomic | GenBank:AL928901 (1) | 145957 nt | ||
Polypeptide | UniProtKB:A0AB32TPW6 (1) | 1228 aa |
- Comparative Orthology
- Alliance
- Lin, Y., Yang, Q., Lin, X., Liu, X., Qian, Y., Xu, D., Cao, N., Han, X., Zhu, Y., Hu, W., He, X., Yu, Z., Kong, X., Zhu, L., Zhong, Z., Liu, K., Zhou, B., Wang, Y., Peng, J., Zhu, W., Wang, J. (2023) Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation. Circulation. 149(8):605-626
- Collery, R.F., Link, B.A. (2019) Precise Short Sequence Insertion in Zebrafish Using a CRISPR/Cas9 Approach to Generate a Constitutively Soluble Lrp2 Protein. Frontiers in cell and developmental biology. 7:167
- Brunet, F.G., Fraser, F.W., Binder, M.J., Smith, A.D., Kintakas, C., Dancevic, C.M., Ward, A.C., McCulloch, D.R. (2015) The evolutionary conservation of the A Disintegrin-like and Metalloproteinase domain with Thrombospondin-1 motif metzincins across vertebrate species and their expression in teleost zebrafish. BMC Evolutionary Biology. 15:22
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huxley-Jones, J., Clarke, T.K., Beck, C., Toubaris, G., Robertson, D.L., and Boot-Handford, R.P. (2007) The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio. BMC Evolutionary Biology. 7(1):63
- Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466
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