Gene
gusb
- ID
- ZDB-GENE-070705-256
- Name
- glucuronidase, beta
- Symbol
- gusb Nomenclature History
- Previous Names
-
- si:ch211-160e1.7
- si:ct573103.7
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have beta-glucuronidase activity and carbohydrate binding activity. Predicted to be involved in glucuronoside catabolic process. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in Sly syndrome. Orthologous to human GUSB (glucuronidase beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Sly syndrome | Alliance | Mucopolysaccharidosis VII | 253220 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR023232 | Glycoside hydrolase, family 2, active site |
| Conserved_site | IPR023230 | Glycoside hydrolase, family 2, conserved site |
| Domain | IPR006102 | Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich |
| Domain | IPR006103 | Glycoside hydrolase family 2, catalytic domain |
| Domain | IPR006104 | Glycosyl hydrolases family 2, sugar binding domain |
| Family | IPR006101 | Glycoside hydrolase, family 2 |
| Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR017853 | Glycoside hydrolase superfamily |
| Homologous_superfamily | IPR036156 | Beta-Galactosidase/glucuronidase domain superfamily |
Domain Details Per Protein
| Protein | Length | Beta-Galactosidase/glucuronidase domain superfamily | Galactose-binding-like domain superfamily | Glycoside hydrolase, family 2 | Glycoside hydrolase, family 2, active site | Glycoside hydrolase family 2, catalytic domain | Glycoside hydrolase, family 2, conserved site | Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich | Glycoside hydrolase superfamily | Glycosyl hydrolases family 2, sugar binding domain | Immunoglobulin-like fold |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QGS9
|
644 |
Interactions and Pathways
No data available
Plasmids