Gene

usp46

ID
ZDB-GENE-070705-213
Name
ubiquitin specific peptidase 46
Symbol
usp46 Nomenclature History
Previous Names
  • si:ch73-16a12.1
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination; regulation of GABAergic synaptic transmission; and regulation of protein stability. Predicted to act upstream of or within proteolysis. Predicted to be active in cytosol and nucleus. Orthologous to human USP46 (ubiquitin specific peptidase 46).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa15815Allele with one point mutationUnknownPremature StopENU
European Zebrafish Resource Center (EZRC) (order this)
Zebrafish International Resource Center (ZIRC) (order this)
1 - 1 of 1
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-usp46N/ATse et al., 2009
1 - 1 of 1
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Human Disease
Associated With usp46 Human Ortholog
No data available
Associated With usp46 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018200 Ubiquitin specific protease, conserved site
Domain IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Family IPR050164 Ubiquitin carboxyl-terminal hydrolases
Homologous_superfamily IPR038765 Papain-like cysteine peptidase superfamily
1 - 4 of 4
Domain Details Per Protein
Protein Additional Resources Length Papain-like cysteine peptidase superfamily Peptidase C19, ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolases Ubiquitin specific protease, conserved site
UniProtKB:A5WWB0 InterPro
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 20
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA usp46-201 (1)
Ensembl
Ensembl 1,417 nt
ZFIN BLAST
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-16A12ZFIN Curated Data
Contained inBACCH73-249K16ZFIN Curated Data
1 - 2 of 2
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Sequences
Type Accession # Sequence Length (nt/aa) Analysis
RNARefSeq:NM_001244981 (1)1139 nt
ZFIN BLASTNCBI BLASTEnsemblUCSC BLAT
GenomicGenBank:CU693368 (1)90103 nt
MegaBLASTEnsembl
PolypeptideUniProtKB:A5WWB0 (2)
ZFIN BLASTSIB BLASTEnsembl Protein Blast
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanUSP464
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseUsp465
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
TSV
1 - 2 of 2
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