Gene
atcaya
- ID
- ZDB-GENE-070705-185
- Name
- ATCAY kinesin light chain interacting caytaxin a
- Symbol
- atcaya Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Acts upstream of or within regulation of cholinergic synaptic transmission. Predicted to be active in cytoplasm. Is expressed in brain; central nervous system; and neurons. Human ortholog(s) of this gene implicated in Cayman type cerebellar ataxia and cerebellar ataxia. Orthologous to human ATCAY (ATCAY kinesin light chain interacting caytaxin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Sun et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-atcaya | N/A | Sun et al., 2015 |
| MO2-atcaya | N/A | Sun et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Cayman type cerebellar ataxia | Alliance | Ataxia, cerebellar, Cayman type | 601238 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Bcl2-/adenovirus E1B 19kDa-interacting protein 2 | CRAL-TRIO lipid binding domain | CRAL-TRIO lipid binding domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9P4L2 | InterPro | 367 | |||
| UniProtKB:F6NPA8 | InterPro | 334 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
atcaya-201
(1)
|
Ensembl | 1,495 nt | ||
| mRNA |
atcaya-202
(1)
|
Ensembl | 2,206 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-63J24 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-49M19 | ZFIN Curated Data | |
| Encodes | EST | cegs2561 | Rauch et al., 2003 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045088 (1) | 2207 nt | ||
| Genomic | GenBank:BX649252 | 205949 nt | ||
| Polypeptide | UniProtKB:A0A8M9P4L2 (1) | 367 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Sullivan, C., Lage, C.R., Yoder, J.A., Postlethwait, J.H., Kim, C.H. (2017) Evolutionary divergence of the vertebrate TNFAIP8 gene family: Applying the spotted gar orthology bridge to understand ohnolog loss in teleosts. PLoS One. 12:e0179517
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Sun, J., Pan, C.Q., Chew, T.W., Liang, F., Burmeister, M., Low, B.C. (2015) BNIP-H Recruits the Cholinergic Machinery to Neurite Terminals to Promote Acetylcholine Signaling and Neuritogenesis. Developmental Cell. 34(5):555-68
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