wdfy3

ID

ZDB-GENE-070705-153

Name

WD repeat and FYVE domain containing 3

Symbol

wdfy3 Nomenclature History

Previous Names

si:ch211-259k10.1

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable metal ion binding activity. Predicted to be involved in aggrephagy. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in primary autosomal dominant microcephaly 18. Orthologous to human WDFY3 (WD repeat and FYVE domain containing 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With wdfy3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary autosomal dominant microcephaly 18	Alliance	?Microcephaly 18, primary, autosomal dominant	617520

Associated With wdfy3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Domain	IPR000306	FYVE zinc finger
Domain	IPR000409	BEACH domain
Domain	IPR017455	Zinc finger, FYVE-related
Domain	IPR023362	PH-BEACH domain
Domain	IPR056252	Alfy-like, armadillo-like repeat domain
Family	IPR051944	BEACH domain-containing protein
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Homologous_superfamily	IPR036372	BEACH domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M2BCS8	InterPro	3525
UniProtKB:A0A8M6Z0T9	InterPro	3496
UniProtKB:A0A8M6YZB2	InterPro	3497
UniProtKB:A0A8M6Z6H7	InterPro	3523
UniProtKB:A0A8M1QLH0	InterPro	3505
UniProtKB:A0A8M9PYD4	InterPro	113
UniProtKB:A0A8M6YYF4	InterPro	3524
UniProtKB:A0AB32TER7	InterPro	134
UniProtKB:A0AB32TQ33	InterPro	3519
UniProtKB:A0AB32TQ95	InterPro	3534
UniProtKB:A0AB32TRM6	InterPro	3517
UniProtKB:A0AB32TRS6	InterPro	3508
UniProtKB:A0AB32TSB9	InterPro	3536
UniProtKB:A0AB32TSM0	InterPro	3507
UniProtKB:A0AB32TU94	InterPro	3522
UniProtKB:A0AB32TUC4	InterPro	3535
UniProtKB:A0AB32TW47	InterPro	3518
UniProtKB:A0AB32TW77	InterPro	3542
UniProtKB:A0AC58JLF5	InterPro	3560
UniProtKB:A0AC58JLG1	InterPro	3532
UniProtKB:A0AC58JLG3	InterPro	3543
UniProtKB:A0AC58JLG5	InterPro	3541
UniProtKB:A0AC58JLG6	InterPro	3518
UniProtKB:A0AC58JLG7	InterPro	3533
UniProtKB:A0AC58JLG8	InterPro	3521
UniProtKB:A0AC58JLG9	InterPro	3514
UniProtKB:A0AC58JLH1	InterPro	3515
UniProtKB:A0AC58JLH3	InterPro	3517
UniProtKB:A0AC58JLH4	InterPro	3513
UniProtKB:A0AC58JLH5	InterPro	3516
UniProtKB:A0AC58JLH7	InterPro	3494
UniProtKB:A0AC58JLH8	InterPro	3505
UniProtKB:A0AC58JLH9	InterPro	3504
UniProtKB:A0AC58JLI0	InterPro	3503
UniProtKB:A0AC58JLI1	InterPro	3519
UniProtKB:A0AC58JLI2	InterPro	3493
UniProtKB:A0AC58JLI3	InterPro	3502
UniProtKB:A0AC58JLI5	InterPro	3474
UniProtKB:A0AC58JLI6	InterPro	3492
UniProtKB:A0AC58JLJ0	InterPro	3477
UniProtKB:A0AC58JLJ1	InterPro	3475
UniProtKB:A0AC58JLJ5	InterPro	3520
UniProtKB:A0AC58JLJ6	InterPro	3511
UniProtKB:A0AC58JLJ9	InterPro	3476
UniProtKB:A0AC58JLL0	InterPro	3491