Gene

wdfy3

ID

ZDB-GENE-070705-153

Name

WD repeat and FYVE domain containing 3

Symbol

wdfy3 Nomenclature History

Previous Names

si:ch211-259k10.1

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have metal ion binding activity. Human ortholog(s) of this gene implicated in primary autosomal dominant microcephaly 18. Orthologous to human WDFY3 (WD repeat and FYVE domain containing 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With wdfy3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary autosomal dominant microcephaly 18	Alliance	?Microcephaly 18, primary, autosomal dominant	617520

Associated With wdfy3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Domain	IPR000306	FYVE zinc finger
Domain	IPR000409	BEACH domain
Domain	IPR017455	Zinc finger, FYVE-related
Domain	IPR023362	PH-BEACH domain
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Homologous_superfamily	IPR036372	BEACH domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	Armadillo-like helical	Armadillo-type fold	BEACH domain	BEACH domain superfamily	Concanavalin A-like lectin/glucanase domain superfamily	FYVE zinc finger	PH-BEACH domain	PH-like domain superfamily	WD40 repeat	WD40 repeat, conserved site	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily	Zinc finger, FYVE/PHD-type	Zinc finger, FYVE-related	Zinc finger, RING/FYVE/PHD-type
UniProtKB:A0A8M2BCS8 InterPro	3525
UniProtKB:A0A8M6Z0T9 InterPro	3496
UniProtKB:A0A8M6YZB2 InterPro	3497
UniProtKB:A0A8M6Z6H7 InterPro	3523
UniProtKB:A0A8M1QLH0 InterPro	3505
UniProtKB:A0A8M9PYD4 InterPro	113
UniProtKB:A0A8M6YYF4 InterPro	3524

Transcripts

Genome Browsers

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	wdfy3-201 (1) Ensembl	Havana	1158 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations